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Anti-cancer Effects of Metformin: Recent Evidences for its Role in Prevention and Treatment of Cancer.
Kheirandish, Masoumeh; Mahboobi, Hamidreza; Yazdanparast, Maryam; Kamal, Warda; Kamal, Mohammad Amjad.
Afiliación
  • Kheirandish M; Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Mahboobi H; Endocrinology and Metabolism Research Center, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Yazdanparast M; Infectious and Tropical Research Center, Hormozgan Health Institute, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
  • Kamal W; Biomediotronics, Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
  • Kamal MA; Biomediotronics, Enzymoics, 7 Peterlee Place, Hebersham, NSW 2770, Australia.
Curr Drug Metab ; 19(9): 793-797, 2018.
Article en En | MEDLINE | ID: mdl-29663879
BACKGROUND: Metformin is widely used for management of Type 2 Diabetes Mellitus (T2DM). Recently growing evidences have shown its anti-cancer effects. The results are mainly from observational studies and thus few information is available concerning the mechanisms of action. METHOD: This paper reviews recent available evidences for anti-cancer effects of metformin. The effects of metformin in specific cancers including colorectal, prostate, pancreatic, renal, cervical, endometrial, gastric, lung, breast, and ovarian cancer are reviewed. RESULTS: Adenosine Monophosphate (AMP)-Activated Protein Kinase (AMPK) plays an important role in mechanism of action of metformin. The anti-cancer mechanisms of metformin include direct and indirect effects. The direct effects of metformin include AMPK-independent and AMPK-dependent effects whereas decrease in glucose level, hyperinsulinemia, and Insulin-like Growth Factor 1 (IGF-1) level are considered its indirect effects. Metformin also decreases both pro-inflammatory cytokines and Nuclear Factor kappa-light-chain-enhancer of activated B cells (NF- κB) and improves the immune response to cancer cells. CONCLUSION: Although the results of recent trials confirm the efficacy of metformin in prevention and treatment of different cancers, the evidences are not adequate enough.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metformina / Neoplasias / Antineoplásicos Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Curr Drug Metab Asunto de la revista: METABOLISMO / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Metformina / Neoplasias / Antineoplásicos Tipo de estudio: Observational_studies Límite: Humans Idioma: En Revista: Curr Drug Metab Asunto de la revista: METABOLISMO / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: Irán Pais de publicación: Países Bajos