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Frequency of Thyroid Dysfunction in Patients With Diabetes Mellitus Before and After Liver Transplantation.
Moura Neto, A; Bovi, T G; Righetto, C M; Fiore, A R; Lot, L T; Perales, S R; de Ataide, E C; Boin, I F S F.
Afiliación
  • Moura Neto A; Discipline of Endocrinology, Internal Medicine Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil. Electronic address: arnaldo.mouraneto@gmail.com.
  • Bovi TG; Discipline of Endocrinology, Internal Medicine Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • Righetto CM; Discipline of Endocrinology, Internal Medicine Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • Fiore AR; Discipline of Endocrinology, Internal Medicine Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • Lot LT; Surgery Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • Perales SR; Surgery Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • de Ataide EC; Surgery Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
  • Boin IFSF; Surgery Department, Faculty of Medical Sciences, University of Campinas, Campinas, Sao Paulo, Brazil.
Transplant Proc ; 50(3): 788-791, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29661439
BACKGROUND: There is mutual influence between the liver and thyroid hormone metabolism. Patients with diabetes mellitus (DM) also have an increased prevalence of thyroid disorders (TDs). The objectives of this study were to evaluate the frequency of TD before and after liver transplantation (LT) in a population of patients with DM as a whole and when categorized by sex. MATERIALS AND METHODS: This was a retrospective study involving interview and medical record analysis of 46 consecutive patients followed at the diabetes mellitus and liver transplantation unit of a tertiary university hospital. RESULTS: Of all patients, 76.1% were men with a median age of 60 years old (interquartile range: 56 to 65 years) and time since LT of 5 years (range, 0.6 to 9 years). Hypertension, hypercholesterolemia, hypertriglyceridemia, alcoholism, and smoking were present in 47.8%, 34.8%, 23.9%, 34.8%, and 30.4% of the patients, respectively. The most frequent immunosuppressant in use was tacrolimus (71.1%). TD was present in 4.3% and 13% before and after LT, respectively (P = .058). In women and men, these frequencies were 9.1% and 18.2% (P = .563), and 2.9% and 11.8% (P = .045), respectively. CONCLUSIONS: Frequency of TD was high both before and after LT. After transplantation, prevalence of TD increased in men and differences between males and females almost disappeared. Further studies are needed to assess if screening for TD before and after LT in patients with DM might be beneficial, especially in men.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Enfermedades de la Tiroides / Trasplante de Hígado / Complicaciones de la Diabetes / Diabetes Mellitus Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complicaciones Posoperatorias / Enfermedades de la Tiroides / Trasplante de Hígado / Complicaciones de la Diabetes / Diabetes Mellitus Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Transplant Proc Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos