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Pneumoperitoneum induced ischemia-reperfusion injury of the peritoneum - Preconditioning may reduce the negative side-effects caused by carbon-dioxide pneumoperitoneum - Pilot study.
Veres, Tünde Gyöngyvér; Takács, Ildikó; Nagy, Tibor; Jancsó, Gábor; Kondor, Ariella; Pótó, László; Vereczkei, András.
Afiliación
  • Veres TG; Department of Surgical Research and Techniques, University of Pécs, Hungary.
  • Takács I; Department of Surgical Research and Techniques, University of Pécs, Hungary.
  • Nagy T; Department of Surgical Research and Techniques, University of Pécs, Hungary.
  • Jancsó G; Department of Surgical Research and Techniques, University of Pécs, Hungary.
  • Kondor A; Surgery Clinic, University of Pécs, Hungary.
  • Pótó L; Institute of Bioanalysis, University of Pécs, Hungary.
  • Vereczkei A; Surgery Clinic, University of Pécs, Hungary.
Clin Hemorheol Microcirc ; 69(4): 481-488, 2018.
Article en En | MEDLINE | ID: mdl-29660910
INTRODUCTION: Laparoscopy is more beneficial than the conventional open technique, however the pneumoperitoneum created may have an ischemic side effect. OBJECTIVE: Our aim was to evaluate the protective effects of preconditioning during laparoscopic cholecystectomies (LC). METHODS: 30 patients were randomized into 2 groups: I. PreC (preconditioning: 5 min. inflation, 5 min. deflation, followed by conventional LC), II: LC (conventional LC). Blood samples were taken before hospitalization (C = control), before surgery, after anaesthesia (B.S.), after surgery (A.S.) and 24 hours after the procedure (24 h). Measured parameters were: malondialdehyde (MDA), reduced glutathione (GSH), sulfhydril groups (-SH), superoxide-dismutase (SOD), catalase (CAT), myeloperoxidase (MPO), length of hospitalization and pain (VAS = visual analogue scale). RESULTS: Compared to the BS levels, no significant changes were detected in SOD's activity and MDA levels. GSH concentrations were significantly increased in the PreC group after operation. SH-, MPO, CAT and liver function enzymes were not significantly different. Hospitalization was shorter in the PreC group. Based on the VAS score patients had less pain in the PreC group. CONCLUSION: Significant differences concerning PreC group were found in GSH values. In the PreC group pain decreased by 2-2.5 units following the procedure, 24 h after surgery, and hospitalisation was also significantly shorter. In our pilot study the potential protective effect of preconditioning could be defined.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peritoneo / Neumoperitoneo / Dióxido de Carbono / Daño por Reperfusión Tipo de estudio: Clinical_trials Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Clin Hemorheol Microcirc Asunto de la revista: ANGIOLOGIA / HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Peritoneo / Neumoperitoneo / Dióxido de Carbono / Daño por Reperfusión Tipo de estudio: Clinical_trials Límite: Adult / Animals / Female / Humans / Male Idioma: En Revista: Clin Hemorheol Microcirc Asunto de la revista: ANGIOLOGIA / HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Hungria Pais de publicación: Países Bajos