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KSHV induces immunoglobulin rearrangements in mature B lymphocytes.
Totonchy, Jennifer; Osborn, Jessica M; Chadburn, Amy; Nabiee, Ramina; Argueta, Lissenya; Mikita, Geoffrey; Cesarman, Ethel.
Afiliación
  • Totonchy J; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States of Amercia.
  • Osborn JM; Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, United States of Amercia.
  • Chadburn A; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States of Amercia.
  • Nabiee R; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States of Amercia.
  • Argueta L; Biomedical and Pharmaceutical Sciences, Chapman University School of Pharmacy, Irvine, CA, United States of Amercia.
  • Mikita G; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States of Amercia.
  • Cesarman E; Pathology and Laboratory Medicine, Weill Cornell Medicine, New York, NY, United States of Amercia.
PLoS Pathog ; 14(4): e1006967, 2018 04.
Article en En | MEDLINE | ID: mdl-29659614
Kaposi sarcoma herpesvirus (KSHV/HHV-8) is a B cell tropic human pathogen, which is present in vivo in monotypic immunoglobulin λ (Igλ) light chain but polyclonal B cells. In the current study, we use cell sorting to infect specific B cell lineages from human tonsil specimens in order to examine the immunophenotypic alterations associated with KSHV infection. We describe IL-6 dependent maturation of naïve B lymphocytes in response to KSHV infection and determine that the Igλ monotypic bias of KSHV infection in vivo is due to viral induction of BCR revision. Infection of immunoglobulin κ (Igκ) naïve B cells induces expression of Igλ and isotypic inclusion, with eventual loss of Igκ. We show that this phenotypic shift occurs via re-induction of Rag-mediated V(D)J recombination. These data explain the selective presence of KSHV in Igλ B cells in vivo and provide the first evidence that a human pathogen can manipulate the molecular mechanisms responsible for immunoglobulin diversity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Reordenamiento Génico / Cadenas lambda de Inmunoglobulina / Infecciones por Herpesviridae / Herpesvirus Humano 8 Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos B / Reordenamiento Génico / Cadenas lambda de Inmunoglobulina / Infecciones por Herpesviridae / Herpesvirus Humano 8 Límite: Humans Idioma: En Revista: PLoS Pathog Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos