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Polyethylene glycol treated allografts not tissue matched nor immunosuppressed rapidly repair sciatic nerve gaps, maintain neuromuscular functions, and restore voluntary behaviors in female rats.
Mikesh, Michelle; Ghergherehchi, Cameron L; Rahesh, Sina; Jagannath, Karthik; Ali, Amir; Sengelaub, Dale R; Trevino, Richard C; Jackson, David M; Tucker, Haley O; Bittner, George D.
Afiliación
  • Mikesh M; Department of Neuroscience, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Ghergherehchi CL; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Rahesh S; Department of Neuroscience, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Jagannath K; Department of Neuroscience, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Ali A; Department of Neuroscience, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Sengelaub DR; Department of Psychological and Brain Sciences, Indiana University, Bloomington, Indiana, 47405, USA.
  • Trevino RC; Department of Orthopedic Surgery, Wellspan Teaching Hospitals, York, PA, USA.
  • Jackson DM; Neuraptive Therapeutics, Lafayette, CO, USA.
  • Tucker HO; Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, 78712, USA.
  • Bittner GD; Department of Neuroscience, University of Texas at Austin, Austin, Texas, 78712, USA.
J Neurosci Res ; 96(7): 1243-1264, 2018 07.
Article en En | MEDLINE | ID: mdl-29659046
Many publications report that ablations of segments of peripheral nerves produce the following unfortunate results: (1) Immediate loss of sensory signaling and motor control; (2) rapid Wallerian degeneration of severed distal axons within days; (3) muscle atrophy within weeks; (4) poor behavioral (functional) recovery after many months, if ever, by slowly-regenerating (∼1mm/d) axon outgrowths from surviving proximal nerve stumps; and (5) Nerve allografts to repair gap injuries are rejected, often even if tissue matched and immunosuppressed. In contrast, using a female rat sciatic nerve model system, we report that neurorrhaphy of allografts plus a well-specified-sequence of solutions (one containing polyethylene glycol: PEG) successfully addresses each of these problems by: (a) Reestablishing axonal continuity/signaling within minutes by nonspecific ally PEG-fusing (connecting) severed motor and sensory axons across each anastomosis; (b) preventing Wallerian degeneration by maintaining many distal segments of inappropriately-reconnected, PEG-fused axons that continuously activate nerve-muscle junctions; (c) maintaining innervation of muscle fibers that undergo much less atrophy than otherwise-denervated muscle fibers; (d) inducing remarkable behavioral recovery to near-unoperated levels within days to weeks, almost certainly by CNS and PNS plasticities well-beyond what most neuroscientists currently imagine; and (e) preventing rejection of PEG-fused donor nerve allografts with no tissue matching or immunosuppression. Similar behavioral results are produced by PEG-fused autografts. All results for Negative Control allografts agree with current neuroscience data 1-5 given above. Hence, PEG-fusion of allografts for repair of ablated peripheral nerve segments expand on previous observations in single-cut injuries, provoke reconsideration of some current neuroscience dogma, and further extend the potential of PEG-fusion in clinical practice.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Peroneo / Polietilenglicoles / Nervio Ciático / Neuropatía Ciática / Regeneración Nerviosa Límite: Animals Idioma: En Revista: J Neurosci Res Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Nervio Peroneo / Polietilenglicoles / Nervio Ciático / Neuropatía Ciática / Regeneración Nerviosa Límite: Animals Idioma: En Revista: J Neurosci Res Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos