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Prognostic Impact of Tumor Mutation Burden in Patients With Completely Resected Non-Small Cell Lung Cancer: Brief Report.
Owada-Ozaki, Yuki; Muto, Satoshi; Takagi, Hironori; Inoue, Takuya; Watanabe, Yuzuru; Fukuhara, Mitsuro; Yamaura, Takumi; Okabe, Naoyuki; Matsumura, Yuki; Hasegawa, Takeo; Ohsugi, Jun; Hoshino, Mika; Shio, Yutaka; Nanamiya, Hideaki; Imai, Jun-Ichi; Isogai, Takao; Watanabe, Shinya; Suzuki, Hiroyuki.
Afiliación
  • Owada-Ozaki Y; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Muto S; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Takagi H; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Inoue T; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Watanabe Y; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Fukuhara M; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Yamaura T; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Okabe N; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Matsumura Y; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Hasegawa T; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Ohsugi J; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Hoshino M; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Shio Y; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan.
  • Nanamiya H; Translational Research Center, Fukushima Medical University, Fukushima, Japan.
  • Imai JI; Translational Research Center, Fukushima Medical University, Fukushima, Japan.
  • Isogai T; Translational Research Center, Fukushima Medical University, Fukushima, Japan.
  • Watanabe S; Translational Research Center, Fukushima Medical University, Fukushima, Japan.
  • Suzuki H; Department of Chest Surgery, Fukushima Medical University, Fukushima, Japan. Electronic address: hiro@fmu.ac.jp.
J Thorac Oncol ; 13(8): 1217-1221, 2018 08.
Article en En | MEDLINE | ID: mdl-29654927
INTRODUCTION: Tumor mutation burden (TMB) is thought to be associated with the amount of neoantigen in the tumor and to have an important role in predicting the effect of immune checkpoint inhibitors. However, the relevance of TMB to prognosis is not yet fully understood. In this study, we investigated the clinical significance of TMB in patients with NSCLC and examined the relationship between TMB and prognosis. METHODS: We calculated TMB within individual tumors by whole-exome sequencing analysis using next-generation sequencing. We included that there were 90 patients with NSCLC who underwent surgery in the Hospital of Fukushima Medical University from 2013 to 2016. No patients received chemotherapy or immunotherapy before surgery. We assessed the correlation between TMB and prognosis. RESULTS: TMB greater than 62 was associated with worse overall survival (OS) of patients with NSCLC (hazard ratio [HR] = 6.633, p = 0.0003). Multivariate analysis showed poor prognosis with high TMB (HR = 12.31, p = 0.019). In patients with stage I NSCLC, higher TMB was associated with worse prognosis for both OS (HR = 7.582, p = 0.0018) and disease-free survival (HR = 6.07, p = 0.0072). CONCLUSIONS: High TMB in NSCLC is a poor prognostic factor. If high TMB is a predictor of the efficacy of immune checkpoint inhibitors, postoperative adjuvant therapy with immune checkpoint inhibitors may contribute to improvement of recurrence and OS.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Thorac Oncol Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Carcinoma de Pulmón de Células no Pequeñas / Neoplasias Pulmonares / Mutación Tipo de estudio: Prognostic_studies Límite: Adult / Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: J Thorac Oncol Año: 2018 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Estados Unidos