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Visual impairment evaluation in 119 children with congenital Zika syndrome.
Ventura, Liana O; Ventura, Camila V; Dias, Natália de C; Vilar, Isabelle G; Gois, Adriana L; Arantes, Tiago E; Fernandes, Luciene C; Chiang, Michael F; Miller, Marilyn T; Lawrence, Linda.
Afiliación
  • Ventura LO; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil; Department of Ophthalmology, HOPE Eye Hospital, Recife, Pernambuco, Brazil. Electronic address: lianaventuramd@gmail.com.
  • Ventura CV; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil; Department of Ophthalmology, HOPE Eye Hospital, Recife, Pernambuco, Brazil.
  • Dias NC; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil.
  • Vilar IG; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil.
  • Gois AL; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil; Department of Ophthalmology, HOPE Eye Hospital, Recife, Pernambuco, Brazil.
  • Arantes TE; Department of Ophthalmology, Altino Ventura Foundation, Recife, Pernambuco, Brazil.
  • Fernandes LC; Department of Low Vision, Federal University of Minas Gerais, Belo Horizonte, Minas Gerias, Brazil.
  • Chiang MF; Department of Ophthalmology, Casey Eye Institute at Oregon Health & Science University, Portland, Oregon.
  • Miller MT; Department of Ophthalmology, University of Illinois, Chicago.
  • Lawrence L; Department of Ophthalmology, University of Kansas School of Medicine, Kansas City, Kansas.
J AAPOS ; 22(3): 218-222.e1, 2018 06.
Article en En | MEDLINE | ID: mdl-29654909
PURPOSE: To assess visual impairment in a large sample of infants with congenital Zika syndrome (CZS) and to compare with a control group using the same assessment protocol. METHODS: The study group was composed of infants with confirmed diagnosis of CZS. Controls were healthy infants matched for age, sex, and socioeconomic status. All infants underwent comprehensive ophthalmologic evaluation including visual acuity, visual function assessment, and visual developmental milestones. RESULTS: The CZS group included 119 infants; the control group, 85 infants. At examination, the mean age of the CZS group was 8.5 ± 1.2 months (range, 6-13 months); of the controls, 8.4 ± 1.8 months (range, 5-12 months; P = 0.598). Binocular Teller Acuity Card (TAC) testing was abnormal in 107 CZS infants and in 4 controls (89.9% versus 5% [P < 0.001]). In the study group, abnormal monocular TAC results were more frequent in eyes with funduscopic alterations (P = 0.008); however, 104 of 123 structurally normal eyes (84.6%) also presented abnormal TAC results. Binocular contrast sensitivity was reduced in 87 of 107 CZS infants and in 8 of 80 controls (81.3% versus 10% [P < 0.001]). The visual development milestones were less achieved by infants with CZS compared to controls (P < 0.001). CONCLUSIONS: Infants with CZS present with severe visual impairment. A protocol for assessment of the ocular findings, visual acuity, and visual developmental milestones tested against age-matched controls is suggested.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Visión / Infecciones Virales del Ojo / Personas con Daño Visual / Infección por el Virus Zika / Microcefalia Tipo de estudio: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: J AAPOS Asunto de la revista: OFTALMOLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos de la Visión / Infecciones Virales del Ojo / Personas con Daño Visual / Infección por el Virus Zika / Microcefalia Tipo de estudio: Guideline / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Female / Humans / Infant / Male Idioma: En Revista: J AAPOS Asunto de la revista: OFTALMOLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos