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Evaluation of Epstein-Barr Virus Salivary Shedding in HIV/AIDS Patients and HAART Use: A Retrospective Cohort Study.
Yan, Yan; Ren, Yong; Chen, Renfang; Hu, Jing; Ji, Yongjia; Yang, Junyang; Shen, Jiayin; Hu, Lvyin; Pei, Hao; Wang, Jun; Qiu, Yuanwang; Lu, Hongzhou; Huang, Lihua.
Afiliación
  • Yan Y; Center of Clinical Laboratory, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Ren Y; Wuxi Institute of Hepatology, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Chen R; The International Joint Research Laboratory for Infection and Immunity (China-Germany), The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Hu J; Wuxi Red Ribbon Care Center of China Red Cross, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Ji Y; Wuxi Institute of Hepatology, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Yang J; Wuxi Red Ribbon Care Center of China Red Cross, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Shen J; The International Joint Research Laboratory for Infection and Immunity (China-Germany), Wuxi School of Medicine, Jiangnan University, Wuxi, 214122, China.
  • Hu L; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Pei H; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Wang J; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Qiu Y; Department of Infectious Diseases, Shanghai Public Health Clinical Center, Fudan University, Shanghai, 201508, China.
  • Lu H; Wuxi Institute of Hepatology, The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
  • Huang L; The International Joint Research Laboratory for Infection and Immunity (China-Germany), The Fifth People's Hospital of Wuxi, Affiliated to Jiangnan University, Wuxi, 214016, China.
Virol Sin ; 33(3): 227-233, 2018 Jun.
Article en En | MEDLINE | ID: mdl-29654554
Little data is available on the evaluation of the occurrence rates of Epstein-Barr virus (EBV) in saliva and relationship with highly active antiretroviral therapy (HAART) use in HIV/AIDS patients in China. We conducted a retrospective cohort study of EBV serological tests for HIV/AIDS patients who were treated in the hospitals for infectious diseases in Wuxi and Shanghai, China from May 2016 to April 2017. The EBV-seropositive samples were identified by ELISA. EBV-specific primers and probes were used for the quantitative detection of viral DNA from saliva via quantitative real-time polymerase chain reaction. CD4 cell counts of the HIV/AIDS patients were detected by a flow cytometry. A total of 372 HIV/AIDS patients were ultimately selected and categorized for this retrospective cohort study. For EBV IgG and IgM, the HIV/AIDS HAART use (H) and non-HAART use (NH) groups had significantly higher seropositive rates than the HIV-negative control group. The HIV/AIDS (NH) group had the highest seropositive rate (IgG, 94.27%; IgM, 68.98%) and the highest incidence of EBV reactivation or infection. For salivary EBV DNA-positive rates and quantities, the HIV/AIDS (H) (73.69%) and the HIV/AIDS (NH) (100%) groups showed significantly higher values than the HIV-negative control group (35.79%, > twofold). Further, the salivary EBV DNA-negative population had significantly higher CD4 cell counts than the EBV DNA-positive population in the HIV/AIDS (H) group and the HIV/AIDS (NH) groups. Thus, HAART use is beneficial in decreasing the EBV salivary shedding in HIV/AIDS patients and indirectly decreases EBV transmission risk.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida / Infecciones por Virus de Epstein-Barr / Terapia Antirretroviral Altamente Activa Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Virol Sin Asunto de la revista: VIROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Saliva / Infecciones por VIH / Síndrome de Inmunodeficiencia Adquirida / Infecciones por Virus de Epstein-Barr / Terapia Antirretroviral Altamente Activa Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Virol Sin Asunto de la revista: VIROLOGIA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos