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Eosinophil and airway nerve interactions in asthma.
Drake, Matthew G; Lebold, Katherine M; Roth-Carter, Quinn R; Pincus, Alexandra B; Blum, Emily D; Proskocil, Becky J; Jacoby, David B; Fryer, Allison D; Nie, Zhenying.
Afiliación
  • Drake MG; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Lebold KM; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Roth-Carter QR; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Pincus AB; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Blum ED; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Proskocil BJ; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Jacoby DB; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Fryer AD; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
  • Nie Z; Division of Pulmonary and Critical Care Medicine, Oregon Health and Science University, Portland, Oregon, USA.
J Leukoc Biol ; 104(1): 61-67, 2018 07.
Article en En | MEDLINE | ID: mdl-29633324
Airway eosinophils are increased in asthma and are especially abundant around airway nerves. Nerves control bronchoconstiction and in asthma, airway hyperreactivity (where airways contract excessively to inhaled stimuli) develops when eosinophils alter both parasympathetic and sensory nerve function. Eosinophils release major basic protein, which is an antagonist of inhibitory M2 muscarinic receptors on parasympathetic nerves. Loss of M2 receptor inhibition potentiates parasympathetic nerve-mediated bronchoconstriction. Eosinophils also increase sensory nerve responsiveness by lowering neurons' activation threshold, stimulating nerve growth, and altering neuropeptide expression. Since sensory nerves activate parasympathetic nerves via a central neuronal reflex, eosinophils' effects on both sensory and parasympathetic nerves potentiate bronchoconstriction. This review explores recent insights into mechanisms and effects of eosinophil and airway nerve interactions in asthma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Broncoconstricción / Eosinófilos / Pulmón Límite: Animals / Humans Idioma: En Revista: J Leukoc Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Asma / Broncoconstricción / Eosinófilos / Pulmón Límite: Animals / Humans Idioma: En Revista: J Leukoc Biol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido