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Efficacy and safety of trimodulin, a novel polyclonal antibody preparation, in patients with severe community-acquired pneumonia: a randomized, placebo-controlled, double-blind, multicenter, phase II trial (CIGMA study).
Welte, Tobias; Dellinger, R Phillip; Ebelt, Henning; Ferrer, Miguel; Opal, Steven M; Singer, Mervyn; Vincent, Jean-Louis; Werdan, Karl; Martin-Loeches, Ignacio; Almirall, Jordi; Artigas, Antonio; Ignacio Ayestarán, Jose; Nuding, Sebastian; Ferrer, Ricard; Sirgo Rodríguez, Gonzalo; Shankar-Hari, Manu; Álvarez-Lerma, Francisco; Riessen, Reimer; Sirvent, Josep-Maria; Kluge, Stefan; Zacharowski, Kai; Bonastre Mora, Juan; Lapp, Harald; Wöbker, Gabriele; Achtzehn, Ute; Brealey, David; Kempa, Axel; Sánchez García, Miguel; Brederlau, Jörg; Kochanek, Matthias; Reschreiter, Henrik Peer; Wise, Matthew P; Belohradsky, Bernd H; Bobenhausen, Iris; Dälken, Benjamin; Dubovy, Patrick; Langohr, Patrick; Mayer, Monika; Schüttrumpf, Jörg; Wartenberg-Demand, Andrea; Wippermann, Ulrike; Wolf, Daniele; Torres, Antoni.
Afiliación
  • Welte T; Department of Pneumology and German Center for Lung Research (DZL), Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany. Welte.Tobias@mh-hannover.de.
  • Dellinger RP; Department of Medicine, Cooper Medical School of Rowan University, Cooper University Health Care, Camden, NJ, USA.
  • Ebelt H; Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Halle (Saale), Germany.
  • Ferrer M; Department of Pneumology, Respiratory Institute, Hospital Clinic of Barcelona, IDIBAPS, CibeRes (CB06/06/0028), University of Barcelona, Barcelona, Spain.
  • Opal SM; Infectious Disease Division, Rhode Island Hospital, Alpert Medical School of Brown University, Providence, RI, USA.
  • Singer M; Bloomsbury Institute of Intensive Care Medicine, University College London, London, UK.
  • Vincent JL; Department of Intensive Care, Erasme University Hospital, Université Libre de Bruxelles, Brussels, Belgium.
  • Werdan K; Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Halle (Saale), Germany.
  • Martin-Loeches I; Multidisciplinary Intensive Care Research Organization (MICRO) Wellcome Trust - HRB Clinical Research Facility (CRF) at St. James's Hospital, Trinity Centre for Health Sciences, Dublin, Ireland.
  • Almirall J; Critical Care Center, CIBER Enfermedades Respiratorias, Corporació Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain.
  • Artigas A; Unitat de Cures Intensives, Hospital de Mataró, Universitat Autónoma de Barcelona, Mataró, Barcelona, Spain.
  • Ignacio Ayestarán J; Critical Care Center, CIBER Enfermedades Respiratorias, Corporació Sanitaria Universitaria Parc Tauli, Autonomous University of Barcelona, Sabadell, Spain.
  • Nuding S; Unidad de Cuidados Intensivos, Hospital Universitario Son Espases, Palma de Mallorca, Spain.
  • Ferrer R; Klinik und Poliklinik für Innere Medizin III, Universitätsklinikum Halle (Saale), Halle (Saale), Germany.
  • Sirgo Rodríguez G; Hospital Universitario Mútua de Terrassa, SODIR-VHIR Research Group, Barcelona, Spain.
  • Shankar-Hari M; Intensive Care Unit, Hospital Universitario Joan XXIII, Instituto de Investigación Sanitaria Pere Virgili, Rovira i Virgili University, Tarragona, Spain.
  • Álvarez-Lerma F; Intensive Care Medicine, Guy's and St. Thomas' NHS Foundation Trust, London, UK.
  • Riessen R; Servicio de Medicina Intensiva, Hospital del Mar, Barcelona, Spain.
  • Sirvent JM; Universitätsklinikum Tübingen, Internistische Intensivstation, Tübingen, Germany.
  • Kluge S; Servicio de Medicina Intensiva, Hospital U. Girona Dr. Josep Trueta, Avinguda França, Girona, Spain.
  • Zacharowski K; Klinik für Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany.
  • Bonastre Mora J; Klinik für Anästhesiologie, Intensivmedizin und Schmerztherapie, Universitätsklinikum Frankfurt, Frankfurt, Germany.
  • Lapp H; Servicio de Cuidados Intensivos Adultos, Hospital Universitari y Politècnico La Fe, Valencia, Spain.
  • Wöbker G; 3 Medizinische Klinik, Kardiologie und Intensivmedizin, Helios Klinikum Erfurt, Erfurt, Germany.
  • Achtzehn U; Klinik für Intensivmedizin, Helios Universitätsklinikum Wuppertal, Wuppertal, Germany.
  • Brealey D; Innere Medizin IV - Pneumologie, Klinikum Chemnitz gGmbH, Chemnitz, Germany.
  • Kempa A; Critical Care Unit, NIHR University College London Hospitals Biomedical Research Centre, University College London Hospitals, NHS Foundation Trust, London, UK.
  • Sánchez García M; Klinik für Allgemeine Innere Medizin, Katharinenhospital, Stuttgart, Germany.
  • Brederlau J; Servicio de Medicina Intensiva, Hospital Clínico San Carlos, Madrid, Spain.
  • Kochanek M; Helios Klinikum Berlin-Buch, Klinik für Intensivmedizin, Berlin, Germany.
  • Reschreiter HP; Department I of Internal Medicine, Intensive Care Unit and Hemostasis, University Hospital of Cologne, Cologne, Germany.
  • Wise MP; Poole Hospital NHS Foundation Trust, Poole, Dorset, UK.
  • Belohradsky BH; Critical Care Unit, University Hospital of Wales, Heath Park, Cardiff, UK.
  • Bobenhausen I; University Children's Hospital Munich, Ludwig-Maximilians University Munich, Munich, Germany.
  • Dälken B; Biotest AG, Dreieich, Germany.
  • Dubovy P; Biotest AG, Dreieich, Germany.
  • Langohr P; Biotest AG, Dreieich, Germany.
  • Mayer M; Biotest AG, Dreieich, Germany.
  • Schüttrumpf J; Biotest AG, Dreieich, Germany.
  • Wartenberg-Demand A; Biotest AG, Dreieich, Germany.
  • Wippermann U; Biotest AG, Dreieich, Germany.
  • Wolf D; Biotest AG, Dreieich, Germany.
  • Torres A; Biotest AG, Dreieich, Germany.
Intensive Care Med ; 44(4): 438-448, 2018 04.
Article en En | MEDLINE | ID: mdl-29632995
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Isotipos de Inmunoglobulinas / Infecciones Comunitarias Adquiridas / Factores Inmunológicos Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged / Newborn Idioma: En Revista: Intensive Care Med Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neumonía / Isotipos de Inmunoglobulinas / Infecciones Comunitarias Adquiridas / Factores Inmunológicos Tipo de estudio: Clinical_trials Límite: Aged / Aged80 / Female / Humans / Male / Middle aged / Newborn Idioma: En Revista: Intensive Care Med Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos