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Impact of selective digestive decontamination without systemic antibiotics in a major heart surgery intensive care unit.
Pérez-Granda, María Jesús; Barrio, José M; Hortal, Javier; Burillo, Almudena; Muñoz, Patricia; Bouza, Emilio.
Afiliación
  • Pérez-Granda MJ; Department of Anesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Ciber de Enfermedades Respiratorias CIBER (CB06/06/0058), Madrid, Spain; Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón and Universidad Complute
  • Barrio JM; Department of Anesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Ciber de Enfermedades Respiratorias CIBER (CB06/06/0058), Madrid, Spain; Instituto de Investigación sanitaria Gregorio Marañón, Madrid, Spain.
  • Hortal J; Department of Anesthesiology, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Ciber de Enfermedades Respiratorias CIBER (CB06/06/0058), Madrid, Spain; Instituto de Investigación sanitaria Gregorio Marañón, Madrid, Spain.
  • Burillo A; Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón and Universidad Complutense de Madrid, Spain; Instituto de Investigación sanitaria Gregorio Marañón, Madrid, Spain.
  • Muñoz P; Ciber de Enfermedades Respiratorias CIBER (CB06/06/0058), Madrid, Spain; Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón and Universidad Complutense de Madrid, Spain; Instituto de Investigación sanitaria Gregorio Marañón, Madrid, Spain; De
  • Bouza E; Ciber de Enfermedades Respiratorias CIBER (CB06/06/0058), Madrid, Spain; Department of Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón and Universidad Complutense de Madrid, Spain; Instituto de Investigación sanitaria Gregorio Marañón, Madrid, Spain; De
J Thorac Cardiovasc Surg ; 156(2): 685-693, 2018 08.
Article en En | MEDLINE | ID: mdl-29628347
PURPOSE: The incidence density of ventilator-associated pneumonia (VAP) is higher in patients undergoing major heart surgery than in other populations, despite the introduction of bundles of preventive measures, because many risk factors are not amenable to intervention. Selective digestive decontamination (SDD) has been shown to be efficacious for decreasing the frequency of VAP, although it has not been incorporated into the routine of most intensive care units. The objective of our study was to evaluate the efficacy of SDD without parenteral antibiotics for preventing VAP in a major heart surgery intensive care unit. METHODS: We compared the incidence of VAP before the introduction of SDD (17 months) and during the 17 months after the introduction of SDD and examined its ecologic influence. RESULTS: The rates of VAP in the overall population before and during the intervention were 16.26/1000 days and 6.80 episodes/1000 days of mechanical ventilation, respectively (P = .01). The rates of VAP in the 173 patients remaining under mechanical ventilation > 48 hours after surgery were, respectively, 25.85/1000 days of mechanical ventilation versus 12.06 episodes/1000 days of mechanical ventilation (P = .04). We found a significant reduction in the number of patients with multidrug-resistant microorganisms (P = .01) in the second period of the study. CONCLUSIONS: Our study shows that SDD without parenteral antibiotics can reduce the incidence of VAP in high-risk patients after major heart surgery, with no significant ecologic influence.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descontaminación / Neumonía Asociada al Ventilador Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Thorac Cardiovasc Surg Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Descontaminación / Neumonía Asociada al Ventilador Tipo de estudio: Risk_factors_studies Límite: Humans Idioma: En Revista: J Thorac Cardiovasc Surg Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos