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Understanding antidepressant discontinuation syndrome (ADS) through preclinical experimental models.
Zabegalov, Konstantin N; Kolesnikova, Tatiana O; Khatsko, Sergey L; Volgin, Andrey D; Yakovlev, Oleg A; Amstislavskaya, Tamara G; Alekseeva, Polina A; Meshalkina, Darya A; Friend, Ashton J; Bao, Wandong; Demin, Konstantin A; Gainetdinov, Raul R; Kalueff, Allan V.
Afiliación
  • Zabegalov KN; Ural Federal University, Ekaterinburg, Russia.
  • Kolesnikova TO; Ural Federal University, Ekaterinburg, Russia.
  • Khatsko SL; Ural Federal University, Ekaterinburg, Russia.
  • Volgin AD; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
  • Yakovlev OA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
  • Amstislavskaya TG; Laboratory of Translational Biopsychiatry, Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia; Department of Neuroscience, Novosibirsk State University, Novosibirsk, Russia.
  • Alekseeva PA; Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia.
  • Meshalkina DA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia.
  • Friend AJ; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; Tulane University School of Science and Engineering, New Orleans, USA.
  • Bao W; School of Pharmacy, Southwest University, Chongqing, China.
  • Demin KA; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia; Institute of Experimental Medicine, Almazov National Medical Research Centre, St. Petersburg, Russia.
  • Gainetdinov RR; Institute of Translational Biomedicine, St. Petersburg State University, St. Petersburg, Russia.
  • Kalueff AV; School of Pharmacy, Southwest University, Chongqing, China; The International Zebrafish Neuroscience Research Consortium (ZNRC), Slidell, LA, USA; Chemical Institute, Ural Federal University, Ekaterinburg, Russia; ZENEREI Research Center, Slidell, LA, USA; Laboratory of Biological Psychiatry, ITBM,
Eur J Pharmacol ; 829: 129-140, 2018 Jun 15.
Article en En | MEDLINE | ID: mdl-29627310
Antidepressant drugs are currently one of the most prescribed medications. In addition to treatment resistance and side effects of antidepressants, their clinical use is further complicated by antidepressant discontinuation syndrome (ADS). ADS is a common problem in patients following the interruption, dose reduction, or discontinuation of antidepressant drugs. Clinically, ADS resembles a classical drug withdrawal syndrome, albeit differing from it because antidepressants generally do not induce addiction. The growing clinical importance and prevalence of ADS necessitate novel experimental (animal) models of this disorder. Currently available preclinical models of ADS are mainly rodent-based, and study mostly serotonergic antidepressants and their combinations. Here, we systematically assess clinical ADS symptoms and discuss current trends and challenges in the field of experimental (animal) models of ADS. We also outline basic mechanisms underlying ADS pathobiology, evaluate its genetic, pharmacological and environmental determinants, and emphasize how using animal models may help generate important translational insights into human ADS condition, its prevention and therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Abstinencia a Sustancias / Antidepresivos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome de Abstinencia a Sustancias / Antidepresivos Tipo de estudio: Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: Eur J Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Países Bajos