Synthesis and characterization of new inhibitors of cholinesterases based on N-phenylcarbamates: In vitro study of inhibitory effect, type of inhibition, lipophilicity and molecular docking.

Vorcáková, Katarína; Májeková, Magdaléna; Horáková, Eva; Drabina, Pavel; Sedlák, Milos; Stepánková, Sárka

Vorcáková, Katarína; Májeková, Magdaléna; Horáková, Eva; Drabina, Pavel; Sedlák, Milos; Stepánková, Sárka.

Afiliación

Vorcáková K; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
Májeková M; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology & Toxicology, Slovak Academy of Science, Bratislava, Slovak Republic.
Horáková E; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
Drabina P; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
Sedlák M; Institute of Organic Chemistry and Technology, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic.
Stepánková S; Department of Biological and Biochemical Sciences, Faculty of Chemical Technology, University of Pardubice, Pardubice, Czech Republic. Electronic address: sarka.stepankova@upce.cz.

Bioorg Chem ; 78: 280-289, 2018 08.

Article en En | MEDLINE | ID: mdl-29621640

Asunto(s)

Acetilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/farmacología; Fenilcarbamatos/farmacología; Animales; Butirilcolinesterasa/metabolismo; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/química; Relación Dosis-Respuesta a Droga; Electrophorus; Caballos; Interacciones Hidrofóbicas e Hidrofílicas; Ligandos; Modelos Moleculares; Estructura Molecular; Fenilcarbamatos/síntesis química; Fenilcarbamatos/química; Relación Estructura-Actividad

Palabras clave

Carbamates; Cholinesterases; IC(50); Molecular modeling; Monosaccharide derivatives; Water bridge

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Acetilcolinesterasa / Inhibidores de la Colinesterasa / Fenilcarbamatos Límite: Animals Idioma: En Revista: Bioorg Chem Año: 2018 Tipo del documento: Article País de afiliación: República Checa Pais de publicación: Estados Unidos

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