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Potent and selective aldo-keto reductase 1C3 (AKR1C3) inhibitors based on the benzoisoxazole moiety: application of a bioisosteric scaffold hopping approach to flufenamic acid.
Pippione, Agnese Chiara; Carnovale, Irene Maria; Bonanni, Davide; Sini, Marcella; Goyal, Parveen; Marini, Elisabetta; Pors, Klaus; Adinolfi, Salvatore; Zonari, Daniele; Festuccia, Claudio; Wahlgren, Weixiao Yuan; Friemann, Rosmarie; Bagnati, Renzo; Boschi, Donatella; Oliaro-Bosso, Simonetta; Lolli, Marco Lucio.
Afiliación
  • Pippione AC; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Carnovale IM; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Bonanni D; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Sini M; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, BD7 1DP, West Yorkshire, UK.
  • Goyal P; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
  • Marini E; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Pors K; Institute of Cancer Therapeutics, School of Pharmacy and Medical Sciences, Faculty of Life Sciences, University of Bradford, BD7 1DP, West Yorkshire, UK.
  • Adinolfi S; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Zonari D; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Festuccia C; Department of Biotechnological and Applied Clinical Sciences, Laboratory of Radiation Biology, University of L'Aquila, via Vetoio snc, Coppito II, 67100, L'Aquila, Italy.
  • Wahlgren WY; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
  • Friemann R; Department of Chemistry and Molecular Biology, University of Gothenburg, Box 462, S-40530, Gothenburg, Sweden.
  • Bagnati R; IRCCS-Istituto di Ricerche Farmacologiche Mario Negri, Via La Masa 19, 20156, Milano, Italy.
  • Boschi D; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy.
  • Oliaro-Bosso S; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy. Electronic address: simona.oliaro@unito.it.
  • Lolli ML; Department of Science and Drug Technology, University of Torino, via Pietro Giuria 9, 10125, Torino, Italy. Electronic address: marco.lolli@unito.it.
Eur J Med Chem ; 150: 930-945, 2018 Apr 25.
Article en En | MEDLINE | ID: mdl-29602039
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoxazoles / Ácido Flufenámico / Inhibidores Enzimáticos / Miembro C3 de la Familia 1 de las Aldo-Ceto Reductasas / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Benzoxazoles / Ácido Flufenámico / Inhibidores Enzimáticos / Miembro C3 de la Familia 1 de las Aldo-Ceto Reductasas / Antineoplásicos Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Francia