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Copper(I)-Catalyzed Synthesis of 1,4-Disubstituted 1,2,3-Triazoles from Azidoformates and Aryl Terminal Alkynes.
Lee, Heejin; Lee, Jae Kyun; Min, Sun-Joon; Seo, Hyeonglim; Lee, Youngbok; Rhee, Hakjune.
Afiliación
  • Lee H; Department of Bionanotechnology , Hanyang University , Sangnok-gu Hanyang Daehak-ro 55 , Ansan , Gyeonggi-do 15588 , Republic of Korea.
  • Lee JK; Center for Neuro-Medicine , Korea Institute of Science and Technology (KIST) , Seongbuk-gu Hwarangro 14-gil 5 , Seoul 136-791 , Republic of Korea.
  • Min SJ; Department of Applied Chemistry , Hanyang University , Sangnok-gu Hanyang Daehak-ro 55 , Ansan , Gyeonggi-do , 15588 , Republic of Korea.
  • Seo H; Department of Bionanotechnology , Hanyang University , Sangnok-gu Hanyang Daehak-ro 55 , Ansan , Gyeonggi-do 15588 , Republic of Korea.
  • Lee Y; Department of Bionanotechnology , Hanyang University , Sangnok-gu Hanyang Daehak-ro 55 , Ansan , Gyeonggi-do 15588 , Republic of Korea.
  • Rhee H; Department of Applied Chemistry , Hanyang University , Sangnok-gu Hanyang Daehak-ro 55 , Ansan , Gyeonggi-do , 15588 , Republic of Korea.
J Org Chem ; 83(8): 4805-4811, 2018 04 20.
Article en En | MEDLINE | ID: mdl-29600859
The copper(I)-catalyzed azide-alkyne cycloaddition reaction has been extensively studied and widely applied in organic synthesis. However, the formation of 1,2,3-triazoles with electron-deficient azide has been a challenging problem. In this report, we have demonstrated the formation of regioselective 1,4-disubstituted 1,2,3-triazoles from various types of aryl terminal alkynes and azidoformates, which are electron-deficient azides, using a commercialized [Cu(CH3CN)4]PF6 copper(I) catalyst under mild conditions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: J Org Chem Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos