Your browser doesn't support javascript.
loading
Beyond ROS clearance: Peroxiredoxins in stress signaling and aging.
Detienne, Giel; De Haes, Wouter; Mergan, Lucas; Edwards, Samantha L; Temmerman, Liesbet; Van Bael, Sven.
Afiliación
  • Detienne G; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Giel.Detienne@kuleuven.be.
  • De Haes W; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Wouter.DeHaes@kuleuven.be.
  • Mergan L; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Lucas.Mergan@kuleuven.be.
  • Edwards SL; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Samantha.Edwards@kuleuven.be.
  • Temmerman L; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Liesbet.Temmerman@kuleuven.be.
  • Van Bael S; Department of Biology, KU Leuven, Naamsestraat 59, 3000 Leuven, Belgium. Electronic address: Sven.VanBael@kuleuven.be.
Ageing Res Rev ; 44: 33-48, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29580920
Antioxidants were long predicted to have lifespan-promoting effects, but in general this prediction has not been well supported. While some antioxidants do seem to have a clear effect on longevity, this may not be primarily as a result of their role in the removal of reactive oxygen species, but rather mediated by other mechanisms such as the modulation of intracellular signaling. In this review we discuss peroxiredoxins, a class of proteinaceous antioxidants with redox signaling and chaperone functions, and their involvement in regulating longevity and stress resistance. Peroxiredoxins have a clear role in the regulation of lifespan and survival of many model organisms, including the mouse, Caenorhabditis elegans and Drosophila melanogaster. Recent research on peroxiredoxins - in these models and beyond - has revealed surprising new insights regarding the interplay between peroxiredoxins and longevity signaling, which will be discussed here in detail. As redox signaling is emerging as a potentially important player in the regulation of longevity and aging, increased knowledge of these fascinating antioxidants and their mode(s) of action is paramount.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Tasa de Depuración Metabólica / Transducción de Señal / Especies Reactivas de Oxígeno / Estrés Oxidativo / Peroxirredoxinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Envejecimiento / Tasa de Depuración Metabólica / Transducción de Señal / Especies Reactivas de Oxígeno / Estrés Oxidativo / Peroxirredoxinas Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Revista: Ageing Res Rev Asunto de la revista: GERIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido