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Stimulus-responsive zinc oxide-functionalized macromolecular humic acid nanocarrier for enhancement of antibacterial activity of ciprofloxacin hydrochloride.
Murugesan, Gowri; Latha, Nachimuthu; Suganya, Kannan; Murugan, Marudhamuthu; Munusamy, Murugan A; Rajan, Mariappan.
Afiliación
  • Murugesan G; Department of Chemistry, Kandaswami Kandar's College, Paramathi Velur, Namakkal District, Tamil Nadu 638182, India.
  • Latha N; Department of Chemistry, Kandaswami Kandar's College, Paramathi Velur, Namakkal District, Tamil Nadu 638182, India. Electronic address: lathaankl@gmail.com.
  • Suganya K; Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India.
  • Murugan M; Department of Microbial Technology, School of Biological Sciences, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India.
  • Munusamy MA; Department of Botany and Microbiology, College of Science, King Saud University, Riyadh 11451, Saudi Arabia.
  • Rajan M; Biomaterials in Medicinal Chemistry Laboratory, Department of Natural Products Chemistry, School of Chemistry, Madurai Kamaraj University, Madurai, Tamil Nadu 625021, India. Electronic address: rajanm153.chem@mkuniversity.org.
Int J Biol Macromol ; 114: 1109-1116, 2018 Jul 15.
Article en En | MEDLINE | ID: mdl-29578024
Macromolecular of naturally occurring humic acid (HA) have garnered interest in the chemical, biological and medicine industry owing to their unique behavior, i.e., strong adsorptive and non-toxic nature. Here, we investigated the functionalization of organic (HA) with inorganic (ZnO) hybrid nanoparticles for topical and site-targeted delivery of ciprofloxacin by simple emulsification techniques. Ciprofloxacin (CIPRO)-encapsulated hybrid nanocarrier constitute an attractive novel drug delivery vehicle for sustained release of antibiotics to bacterial infection sites in an extended and controlled manner. The analytical characteristics of the designed system were thoroughly investigated by FTIR, XRD, SEM/EDAX, and TEM. The drug release of ciprofloxacin over 24h was 87.5%, 98.03%, 97.44%, and 97.24% for pH2.5, 5.5, 6.8, and 8.0, respectively. The antibacterial activities results confirmed that the CIPRO-encapsulated hybrid nanocarrier showed excellent growth inhibition against microorganisms. This hybrid nanocarrier loaded with antibiotics represents a promising approach for targeted and controlled drug delivery to infected sites.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Bacillus cereus / Óxido de Zinc / Portadores de Fármacos / Ciprofloxacina / Nanopartículas / Sustancias Húmicas / Antibacterianos Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Pseudomonas aeruginosa / Bacillus cereus / Óxido de Zinc / Portadores de Fármacos / Ciprofloxacina / Nanopartículas / Sustancias Húmicas / Antibacterianos Idioma: En Revista: Int J Biol Macromol Año: 2018 Tipo del documento: Article País de afiliación: India Pais de publicación: Países Bajos