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Inhibition of RhoA reduces propofol-mediated growth cone collapse, axonal transport impairment, loss of synaptic connectivity, and behavioural deficits.
Pearn, M L; Schilling, J M; Jian, M; Egawa, J; Wu, C; Mandyam, C D; Fannon-Pavlich, M J; Nguyen, U; Bertoglio, J; Kodama, M; Mahata, S K; DerMardirossian, C; Lemkuil, B P; Han, R; Mobley, W C; Patel, H H; Patel, P M; Head, B P.
Afiliación
  • Pearn ML; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Schilling JM; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Jian M; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Egawa J; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Wu C; Department of Neurosciences, UCSD, San Diego, CA, USA.
  • Mandyam CD; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Fannon-Pavlich MJ; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Nguyen U; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Bertoglio J; INSERM U749, Institut Gustave Roussy, Universite Paris-sud, Paris, France.
  • Kodama M; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA; Metabolic Physiology and Ultrastructural Biology Laboratory, UCSD, San Diego CA, USA; Department of Anesthesiology, National Defense Medical College, Tokorozawa, Saitama, Ja
  • Mahata SK; Metabolic Physiology and Ultrastructural Biology Laboratory, UCSD, San Diego CA, USA.
  • DerMardirossian C; Department of Immunology and Microbial Sciences, TSRI, La Jolla, CA, USA; Department of Cell and Molecular Biology, TSRI, La Jolla, CA, USA.
  • Lemkuil BP; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Han R; Department of Anesthesiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
  • Mobley WC; Department of Neurosciences, UCSD, San Diego, CA, USA.
  • Patel HH; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Patel PM; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA.
  • Head BP; Veterans Affairs San Diego Healthcare System, UCSD, San Diego CA, USA; Department of Anesthesiology, UCSD, San Diego, CA, USA. Electronic address: bhead@ucsd.edu.
Br J Anaesth ; 120(4): 745-760, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29576115
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Axonal / Sinapsis / Conducta Animal / Propofol / Conos de Crecimiento / Proteína de Unión al GTP rhoA Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Anaesth Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transporte Axonal / Sinapsis / Conducta Animal / Propofol / Conos de Crecimiento / Proteína de Unión al GTP rhoA Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: Br J Anaesth Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido