Inhibition of yes-associated protein suppresses brain metastasis of human lung adenocarcinoma in a murine model.

Hsu, Ping-Chih; Miao, Jinbai; Huang, Zhen; Yang, Yi-Lin; Xu, Zhidong; You, Joanna; Dai, Yuyuan; Yeh, Che-Chung; Chan, Geraldine; Liu, Shu; Urisman, Anatoly; Yang, Cheng-Ta; Jablons, David M; You, Liang

Hsu, Ping-Chih; Miao, Jinbai; Huang, Zhen; Yang, Yi-Lin; Xu, Zhidong; You, Joanna; Dai, Yuyuan; Yeh, Che-Chung; Chan, Geraldine; Liu, Shu; Urisman, Anatoly; Yang, Cheng-Ta; Jablons, David M; You, Liang.

Afiliación

Hsu PC; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Miao J; Department of Thoracic Medicine, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan.
Huang Z; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Yang YL; Department of Thoracic Surgery, Beijing Chao-Yang Hospital, Affiliated with Capital Medical University, Beijing, China.
Xu Z; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
You J; Department of Hepatobiliary Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Dai Y; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Yeh CC; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Chan G; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Liu S; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Urisman A; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Yang CT; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
Jablons DM; Department of Surgery, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, USA.
You L; Department of Pathology, University of California, San Francisco, CA, USA.

J Cell Mol Med ; 22(6): 3073-3085, 2018 06.

Article en En | MEDLINE | ID: mdl-29575527

Asunto(s)

Proteínas Adaptadoras Transductoras de Señales/genética; Adenocarcinoma del Pulmón/genética; Neoplasias Encefálicas/genética; Carcinogénesis/genética; Fosfoproteínas/genética; Proteínas Adaptadoras Transductoras de Señales/antagonistas & inhibidores; Adenocarcinoma del Pulmón/patología; Adenocarcinoma del Pulmón/terapia; Animales; Neoplasias Encefálicas/patología; Neoplasias Encefálicas/secundario; Neoplasias Encefálicas/terapia; Línea Celular Tumoral; Factor de Crecimiento del Tejido Conjuntivo/genética; Modelos Animales de Enfermedad; Resistencia a Antineoplásicos/genética; Receptores ErbB/genética; Regulación Neoplásica de la Expresión Génica/genética; Humanos; Ratones; Mutación; Fosfoproteínas/antagonistas & inhibidores; Proteínas Proto-Oncogénicas p21(ras)/genética; ARN Interferente Pequeño/administración & dosificación; Transducción de Señal; Factores de Transcripción; Ensayos Antitumor por Modelo de Xenoinjerto; Proteínas Señalizadoras YAP

Palabras clave

Hippo signalling; K-ras mutation; lung adenocarcinoma; metastasis; yes-associated protein

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Neoplasias Encefálicas / Proteínas Adaptadoras Transductoras de Señales / Carcinogénesis / Adenocarcinoma del Pulmón Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Humans Idioma: En Revista: J Cell Mol Med Asunto de la revista: BIOLOGIA MOLECULAR Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido

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