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Mercury bioaccumulation and its toxic effects in rats fed with methylmercury polluted rice.
Li, Ping; Du, Buyun; Chan, Hing Man; Feng, Xinbin; Li, Baixiang.
Afiliación
  • Li P; State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China.
  • Du B; State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Chan HM; Centre for Advanced Research in Environmental Genomics, University of Ottawa, Ottawa K1N 6N5, Canada.
  • Feng X; State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China. Electronic address: fengxinbin@vip.skleg.cn.
  • Li B; Department of Toxicology, Public Health College, Harbin Medical University, Harbin 150081, China. Electronic address: libaixianghmu@aliyun.com.
Sci Total Environ ; 633: 93-99, 2018 Aug 15.
Article en En | MEDLINE | ID: mdl-29573695
Recent evidence indicated that methylmercury (MeHg) contaminated rice can be a significant source of MeHg human exposure, but the health implications are not known. The objective of this study was to study the kinetics, speciation, and effects of MeHg contaminated rice using a rat model. Five groups of adult Sprague-Dawley rats (n=10 in each group) were fed control rice, low (10ng/g MeHg) and high (25ng/g MeHg) MeHg contaminated rice. Two groups of the positive control were fed control rice spiked with the same levels of MeHgCl. Short-term exposure to low level of spiked MeHgCl stimulated the growth of male rats while long-term exposure to spiked MeHgCl inhibited the growth in female rats. There was no temporal variation of total mercury (THg) concentrations in the rat fecal samples from each group, and the THg concentrations significantly correlated with the inorganic Hg concentrations in the feeding rice. There were significant differences in the accumulation of THg and MeHg among different groups and different organs. THg and MeHg concentrations in the kidney were the highest among the organs examined. The blood and brain had high percentages of THg as MeHg, which indicates that MeHg can easily pass through the blood-brain barrier and has a high affinity for brain tissue. Exposure to rice containing 25ng/g MeHg decreased antioxidant function and damaged the nervous system in rats, but no significant effects were found in the group fed with rice containing 10ng/g MeHg. MeHgCys in rice is less toxic than spiked MeHgCl to rats. The toxicity of MeHg both decided by its concentration and speciation.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes del Suelo / Mercurio Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Contaminantes del Suelo / Mercurio Límite: Animals Idioma: En Revista: Sci Total Environ Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Países Bajos