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Inorganic arsenic causes apoptosis cell death and immunotoxicity on European sea bass (Dicentrarchus labrax).
Cordero, Héctor; Morcillo, Patricia; Martínez, Salvadora; Meseguer, José; Pérez-Sirvent, Carmen; Chaves-Pozo, Elena; Martínez-Sanchez, María José; Cuesta, Alberto; Ángeles Esteban, M.
Afiliación
  • Cordero H; Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Morcillo P; Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Bronx, 10461, NY, USA.
  • Martínez S; Department of Agricultural Chemistry, Geology and Pedology, Faculty of Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Meseguer J; Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Pérez-Sirvent C; Department of Agricultural Chemistry, Geology and Pedology, Faculty of Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Chaves-Pozo E; Centro Oceanográfico de Murcia, Instituto Español de Oceanografía (IEO), Carretera de la Azohía s/n., 30860 Puerto de Mazarrón, Murcia, Spain.
  • Martínez-Sanchez MJ; Department of Agricultural Chemistry, Geology and Pedology, Faculty of Chemistry, Campus Regional de Excelencia Internacional "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Cuesta A; Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain.
  • Ángeles Esteban M; Fish Innate Immune System Group, Department of Cell Biology and Histology, Faculty of Biology, Regional Campus of International Excellence "Campus Mare Nostrum", University of Murcia, 30100 Murcia, Spain. Electronic address: aesteban@um.es.
Mar Pollut Bull ; 128: 324-332, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29571380
Inorganic arsenic (As) is one of the most toxic pollutants in the water. We have studied their effects on the marine teleost European sea bass (Dicentrarchus labrax) at 2 and 10 days of 5 µM of As2O3 (sub-lethal doses) waterborne exposure. Arsenic accumulates in liver and gill tissues. The expression profile of five genes (bax, blc2, casp3, casp8 and casp9) involved in apoptosis cell death confirmed apoptotic effects in liver, slight changes in gill and no effects in skin according with the histopathology findings. Total IgM level and peroxidase activities were increased at 2 and 10 days, respectively. The bactericidal activity was decreased at 2 days after As exposure. A general decrease of cellular immune activities with significant differences in the case of respiratory burst activity was observed after 2 and 10 days of exposure. This work describes for the first time the effects of As exposure on European sea bass.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Fagocitosis / Contaminantes Químicos del Agua / Lubina / Apoptosis Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Mar Pollut Bull Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Óxidos / Fagocitosis / Contaminantes Químicos del Agua / Lubina / Apoptosis Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Mar Pollut Bull Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido