Your browser doesn't support javascript.
loading
Surgical re-excision vs. observation for histologically dysplastic naevi: a systematic review of associated clinical outcomes.
Vuong, K T; Walker, J; Powell, H B; Thomas, N E; Jonas, D E; Adamson, A S.
Afiliación
  • Vuong KT; University of North Carolina School of Medicine, Chapel Hill, NC, U.S.A.
  • Walker J; Health Sciences Library, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.
  • Powell HB; University of North Carolina School of Medicine, Chapel Hill, NC, U.S.A.
  • Thomas NE; Department of Dermatology, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.
  • Jonas DE; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.
  • Adamson AS; Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, U.S.A.
Br J Dermatol ; 179(3): 590-598, 2018 09.
Article en En | MEDLINE | ID: mdl-29570779
BACKGROUND: The management of histologically dysplastic naevi (HDN) with re-excision vs. observation remains controversial because of lack of evidence about associated melanoma outcomes. OBJECTIVES: To assess published data on the development of biopsy-site primary cutaneous melanoma among biopsy-proven HDN managed with either re-excision or observation. METHODS: A systematic review of all published data: a total of 5293 records were screened, 18 articles were assessed in full text and 12 studies met inclusion criteria. No controlled trials were identified. RESULTS: Most studies (11 of 12, 92%) were retrospective chart reviews, and one was both a cross-sectional and cohort study. Many studies (nine of 12, 75%) had no head-to-head comparison groups and either only reported HDN that were re-excised or observed. A total of 2673 (1535 observed vs. 1138 re-excised) HDN of various grades were included. Follow-up varied between 2 weeks and 30 years. Nine studies reported that no melanomas developed. Eleven biopsy-site melanomas developed across three of the studies, six among observed lesions (0·39%) and five among re-excised lesions (0·44%). CONCLUSIONS: Based upon the available evidence the rates of biopsy-site primary melanoma were similarly low among observed lesions and re-excised lesions. This suggests that HDNs can be observed with minimal adverse melanoma-associated outcomes. However, all included articles were of low quality and further prospective trials could better guide clinical decision making.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Síndrome del Nevo Displásico / Espera Vigilante / Procedimientos Quirúrgicos Dermatologicos / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Br J Dermatol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Síndrome del Nevo Displásico / Espera Vigilante / Procedimientos Quirúrgicos Dermatologicos / Melanoma Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Límite: Humans Idioma: En Revista: Br J Dermatol Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido