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Use of Antiepileptic Drugs and Dementia Risk-an Analysis of Finnish Health Register and German Health Insurance Data.
Taipale, Heidi; Gomm, Willy; Broich, Karl; Maier, Wolfgang; Tolppanen, Anna-Maija; Tanskanen, Antti; Tiihonen, Jari; Hartikainen, Sirpa; Haenisch, Britta.
Afiliación
  • Taipale H; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Gomm W; Kuopio Research Center for Geriatric Care, School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Broich K; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
  • Maier W; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Tolppanen AM; Federal Institute for Drugs and Medical Devices, Bonn, Germany.
  • Tanskanen A; German Center for Neurodegenerative Diseases, Bonn, Germany.
  • Tiihonen J; Department of Psychiatry, University of Bonn, Bonn, Germany.
  • Hartikainen S; School of Pharmacy, University of Eastern Finland, Kuopio, Finland.
  • Haenisch B; Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
J Am Geriatr Soc ; 66(6): 1123-1129, 2018 07.
Article en En | MEDLINE | ID: mdl-29566430
OBJECTIVES: To evaluate the association between regular antiepileptic drug (AED) use and incident dementia. DESIGN: Case-control analysis. SETTING: Finnish public health register and German health insurance data. PARTICIPANTS: Individuals with dementia of any type (German data, N=20,325) and Alzheimer's disease (AD; Finnish data, N=70,718) were matched with up to four control persons without dementia. MEASUREMENTS: We analyzed the association between regular AED use and dementia. To address potential protopathic bias, a lag time of 2 years between AED use and dementia diagnosis was introduced. Odds ratios (ORs) were calculated by applying conditional logistic regression, adjusted for potential confounding factors such as comorbidities and polypharmacy. RESULTS: Regular AED use was more frequent in individuals with dementia than controls. Regular use of AEDs was associated with a significantly greater risk of incident dementia (adjusted OR=1.28, 95% confidence interval (CI)=1.14-1.44) and AD (adjusted OR=1.15, 95% CI=1.09-1.22) than no AED use. We also detected a trend toward greater risk of dementia with higher exposure. When AEDs with and without known cognitive adverse effects (CAEs) were compared, a significantly greater risk of dementia was observed for substances with known CAEs (dementia: OR=1.59, 95% CI=1.36-1.86; AD: OR=1.19, 95% CI=1.11-1.27). CONCLUSION: AEDs, especially those with known CAEs, may contribute to incident dementia and AD in older persons.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Anticonvulsivantes Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Am Geriatr Soc Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Demencia / Anticonvulsivantes Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male País/Región como asunto: Europa Idioma: En Revista: J Am Geriatr Soc Año: 2018 Tipo del documento: Article País de afiliación: Finlandia Pais de publicación: Estados Unidos