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High Prevalence of Toxigenic and Nontoxigenic Clostridium difficile Strains in Malaysia.
Riley, Thomas V; Collins, Deirdre A; Karunakaran, Rina; Kahar, Maria Abdul; Adnan, Ariza; Hassan, Siti Asma; Zainul, Nadiah Hanim; Rustam, F R Mohammed; Wahab, Z Abd; Ramli, Ramliza; Lee, Yeong Yeh; Hassan, Hamimah.
Afiliación
  • Riley TV; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia thomas.riley@uwa.edu.au.
  • Collins DA; Department of Microbiology, PathWest Laboratory Medicine, Nedlands, Australia.
  • Karunakaran R; School of Veterinary and Life Sciences, Murdoch University, Murdoch, Australia.
  • Kahar MA; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia.
  • Adnan A; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Hassan SA; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Zainul NH; Department of Medical Microbiology, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia.
  • Rustam FRM; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
  • Wahab ZA; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Malaysia.
  • Ramli R; Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh, Malaysia.
  • Lee YY; Sungai Buloh Hospital, Sungai Buloh, Malaysia.
  • Hassan H; Department of Microbiology and Immunology, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia.
J Clin Microbiol ; 56(6)2018 06.
Article en En | MEDLINE | ID: mdl-29563206
Accumulating evidence shows a high prevalence of Clostridium difficile in Southeast Asia associated with a range of clinical presentations. However, severe infections are rarely reported. We investigated C. difficile infection (CDI) across four hospitals in Kuala Lumpur and Kota Bharu, Malaysia. Enzyme immunoassays for glutamate dehydrogenase (GDH) and toxin A or B were performed on diarrheal stool specimens collected from patients in 2015 and 2016. Specimens were also cultured and isolates of C. difficile characterized by PCR ribotyping and detection of toxin genes. In total, 437 specimens were collected and fecal toxin was detected in 3.0%. A further 16.2% of specimens were GDH positive and toxin negative. After culture, toxigenic strains were isolated from 10.3% and nontoxigenic strains from 12.4% of specimens. The most prevalent PCR ribotypes (RTs) were RT 017 (20.0%) and RT 043 (10.0%). The high prevalence of RT 017 and nontoxigenic strains in Malaysia and in neighboring Thailand and Indonesia suggests that they localize to the region of Southeast Asia, with an implication that they may mediate the burden of CDI in the region.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Toxinas Bacterianas / Clostridioides difficile / Infecciones por Clostridium / Enterotoxinas Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Clin Microbiol Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas Bacterianas / Toxinas Bacterianas / Clostridioides difficile / Infecciones por Clostridium / Enterotoxinas Tipo de estudio: Prevalence_studies / Risk_factors_studies Límite: Adolescent / Adult / Aged / Aged80 / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: J Clin Microbiol Año: 2018 Tipo del documento: Article País de afiliación: Australia Pais de publicación: Estados Unidos