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Gallic Acid Content and an Antioxidant Mechanism Are Responsible for the Antiproliferative Activity of 'Ataulfo' Mango Peel on LS180 Cells.
Velderrain-Rodríguez, Gustavo R; Torres-Moreno, Heriberto; Villegas-Ochoa, Mónica A; Ayala-Zavala, J Fernando; Robles-Zepeda, Ramón E; Wall-Medrano, Abraham; González-Aguilar, Gustavo A.
Afiliación
  • Velderrain-Rodríguez GR; Coordination of Food Technology of Plant Origin, Center for Research in Food and Development, A.C. (CIAD), Carretera a la Victoria Km 0.6. C.P., Hermosillo 83304, Mexico. grvelderrain@gmail.com.
  • Torres-Moreno H; Department of Biological Chemistry., Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N Col. Centro, C.P., Hermosillo 83000, Mexico. mvillegas@ciad.mx.
  • Villegas-Ochoa MA; Coordination of Food Technology of Plant Origin, Center for Research in Food and Development, A.C. (CIAD), Carretera a la Victoria Km 0.6. C.P., Hermosillo 83304, Mexico. jayala@ciad.mc.
  • Ayala-Zavala JF; Coordination of Food Technology of Plant Origin, Center for Research in Food and Development, A.C. (CIAD), Carretera a la Victoria Km 0.6. C.P., Hermosillo 83304, Mexico. heriberto.torres@unison.mx.
  • Robles-Zepeda RE; Department of Biological Chemistry., Universidad de Sonora, Blvd. Luis Encinas y Rosales S/N Col. Centro, C.P., Hermosillo 83000, Mexico. rrobles@guayacan.uson.mx.
  • Wall-Medrano A; Biomedical Sciences Institute, Autonomous University of Ciudad Juarez, Anillo Envolvente del Pronaf y Estocolmo S/N, Ciudad Juárez 32310, Chihuahua, Mexico. awall@uacj.mx.
  • González-Aguilar GA; Coordination of Food Technology of Plant Origin, Center for Research in Food and Development, A.C. (CIAD), Carretera a la Victoria Km 0.6. C.P., Hermosillo 83304, Mexico. gustavo@ciad.mx.
Molecules ; 23(3)2018 Mar 19.
Article en En | MEDLINE | ID: mdl-29562699
Mango "Ataulfo" peel is a rich source of polyphenols (PP), with antioxidant and anti-cancer properties; however, it is unknown whether such antiproliferative activity is related to PP's antioxidant activity. The content (HPLC-DAD), antioxidant (DPPH, FRAP, ORAC), and antiproliferative activities (MTT) of free (FP) and chemically-released PP from mango 'Ataulfo' peel after alkaline (AKP) and acid (AP) hydrolysis, were evaluated. AKP fraction was higher (µg/g DW) in gallic acid (GA; 23,816 ± 284) than AP (5610 ± 8) of FR (not detected) fractions. AKP fraction and GA showed the highest antioxidant activity (DPPH/FRAP/ORAC) and GA's antioxidant activity follows a single electron transfer (SET) mechanism. AKP and GA also showed the best antiproliferative activity against human colon adenocarcinoma cells (LS180; IC50 (µg/mL) 138.2 ± 2.5 and 45.7 ± 5.2) and mouse connective cells (L929; 93.5 ± 7.7 and 65.3 ± 1.2); Cheminformatics confirmed the hydrophilic nature (LogP, 0.6) and a good absorption capacity (75%) for GA. Data suggests that GA's antiproliferative activity appears to be related to its antioxidant mechanism, although other mechanisms after its absorption could also be involved.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mangifera / Ácido Gálico / Antioxidantes Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Mangifera / Ácido Gálico / Antioxidantes Límite: Humans Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: México Pais de publicación: Suiza