Your browser doesn't support javascript.
loading
Reconstructing the genetic history of late Neanderthals.
Hajdinjak, Mateja; Fu, Qiaomei; Hübner, Alexander; Petr, Martin; Mafessoni, Fabrizio; Grote, Steffi; Skoglund, Pontus; Narasimham, Vagheesh; Rougier, Hélène; Crevecoeur, Isabelle; Semal, Patrick; Soressi, Marie; Talamo, Sahra; Hublin, Jean-Jacques; Gusic, Ivan; Kucan, Zeljko; Rudan, Pavao; Golovanova, Liubov V; Doronichev, Vladimir B; Posth, Cosimo; Krause, Johannes; Korlevic, Petra; Nagel, Sarah; Nickel, Birgit; Slatkin, Montgomery; Patterson, Nick; Reich, David; Prüfer, Kay; Meyer, Matthias; Pääbo, Svante; Kelso, Janet.
Afiliación
  • Hajdinjak M; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Fu Q; Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, IVPP, CAS, Beijing 100044, China.
  • Hübner A; CAS Center for Excellence in Life and Paleoenvironment, Beijing 100044, China.
  • Petr M; University of Chinese Academy of Sciences, Beijing 100049, China.
  • Mafessoni F; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Grote S; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Skoglund P; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Narasimham V; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Rougier H; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Crevecoeur I; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
  • Semal P; Department of Anthropology, California State University Northridge, Northridge, California 91330-8244, USA.
  • Soressi M; Université de Bordeaux, CNRS, UMR 5199-PACEA, 33615 Pessac Cedex, France.
  • Talamo S; Royal Belgian Institute of Natural Sciences, 1000 Brussels, Belgium.
  • Hublin JJ; Faculty of Archaeology, Leiden University, 2300 RA Leiden, The Netherlands.
  • Gusic I; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Kucan Z; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Rudan P; Department of Human Evolution, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Golovanova LV; Croatian Academy of Sciences and Arts, HR-10000 Zagreb, Croatia.
  • Doronichev VB; Croatian Academy of Sciences and Arts, HR-10000 Zagreb, Croatia.
  • Posth C; Croatian Academy of Sciences and Arts, HR-10000 Zagreb, Croatia.
  • Krause J; ANO Laboratory of Prehistory 14 Linia 3-11, St Petersburg 1990 34, Russia.
  • Korlevic P; ANO Laboratory of Prehistory 14 Linia 3-11, St Petersburg 1990 34, Russia.
  • Nagel S; Max Planck Institute for the Science of Human History, 07745 Jena, Germany.
  • Nickel B; Institute for Archaeological Sciences, University of Tübingen, Rümelin Strasse 23, 72070 Tübingen, Germany.
  • Slatkin M; Max Planck Institute for the Science of Human History, 07745 Jena, Germany.
  • Patterson N; Institute for Archaeological Sciences, University of Tübingen, Rümelin Strasse 23, 72070 Tübingen, Germany.
  • Reich D; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Prüfer K; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Meyer M; Department of Evolutionary Genetics, Max Planck Institute for Evolutionary Anthropology, D-04103 Leipzig, Germany.
  • Pääbo S; Department of Integrative Biology, University of California, Berkeley, California 94720-3140, USA.
  • Kelso J; Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Nature ; 555(7698): 652-656, 2018 03 29.
Article en En | MEDLINE | ID: mdl-29562232
Although it has previously been shown that Neanderthals contributed DNA to modern humans, not much is known about the genetic diversity of Neanderthals or the relationship between late Neanderthal populations at the time at which their last interactions with early modern humans occurred and before they eventually disappeared. Our ability to retrieve DNA from a larger number of Neanderthal individuals has been limited by poor preservation of endogenous DNA and contamination of Neanderthal skeletal remains by large amounts of microbial and present-day human DNA. Here we use hypochlorite treatment of as little as 9 mg of bone or tooth powder to generate between 1- and 2.7-fold genomic coverage of five Neanderthals who lived around 39,000 to 47,000 years ago (that is, late Neanderthals), thereby doubling the number of Neanderthals for which genome sequences are available. Genetic similarity among late Neanderthals is well predicted by their geographical location, and comparison to the genome of an older Neanderthal from the Caucasus indicates that a population turnover is likely to have occurred, either in the Caucasus or throughout Europe, towards the end of Neanderthal history. We find that the bulk of Neanderthal gene flow into early modern humans originated from one or more source populations that diverged from the Neanderthals that were studied here at least 70,000 years ago, but after they split from a previously sequenced Neanderthal from Siberia around 150,000 years ago. Although four of the Neanderthals studied here post-date the putative arrival of early modern humans into Europe, we do not detect any recent gene flow from early modern humans in their ancestry.
Asunto(s)
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma / Hombre de Neandertal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male País/Región como asunto: Africa / Asia / Europa Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma / Hombre de Neandertal Tipo de estudio: Prognostic_studies Límite: Animals / Female / Humans / Male País/Región como asunto: Africa / Asia / Europa Idioma: En Revista: Nature Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido