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Complement C1q stimulates the progression of hepatocellular tumor through the activation of discoidin domain receptor 1.
Lee, Ji-Hyun; Poudel, Barun; Ki, Hyeon-Hui; Nepali, Sarmila; Lee, Young-Mi; Shin, Jeon-Soo; Kim, Dae-Ki.
Afiliación
  • Lee JH; Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea.
  • Poudel B; Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea.
  • Ki HH; Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea.
  • Nepali S; Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea.
  • Lee YM; Department of Oriental Pharmacy, College of Pharmacy and Wonkwang-Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeollabuk-do, 54538, Republic of Korea.
  • Shin JS; Department of Microbiology, BK21 PLUS for Medical Sciences, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.
  • Kim DK; Department of Immunology and Institute for Medical Sciences, Chonbuk National University Medical School, Jeonju, Jeollabuk-do, 54907, Republic of Korea. daekim@jbnu.ac.kr.
Sci Rep ; 8(1): 4908, 2018 03 20.
Article en En | MEDLINE | ID: mdl-29559654
C1q is known to perform several functions in addition to the role it plays in complement activation. C1q contains a collagen-like portion and DDR1 (discoidin domain receptor 1) is a well-known collagen receptor. Accordingly, we hypothesized C1q might be a novel ligand of DDR1. This study shows for the first time C1q directly induces the activation and upregulation of DDR1, and that this leads to enhanced migration and invasion of HepG2 cells. In addition, C1q was found to induce the activations of mitogen-activated protein kinases (MAPKs) and phosphoinositide 3-kinase (PI3K)/Akt signaling, and to increase the expressions of matrix metalloproteinases (MMP2 and 9). Our results reveal a relationship between C1q and DDR1 and suggest C1q-induced DDR1 activation signaling may be involved in the progression of hepatocellular carcinoma.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C1q / Carcinoma Hepatocelular / Receptor con Dominio Discoidina 1 / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complemento C1q / Carcinoma Hepatocelular / Receptor con Dominio Discoidina 1 / Neoplasias Hepáticas Límite: Humans Idioma: En Revista: Sci Rep Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido