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Analysis of Chloramphenicol and Two Metabolites in Crab and Shrimp Following Waterborne Exposure.
Jester, Edward L E; Loader, Jared I; Quintana, Harold A Flores; Said, Kathleen R El; Benner, Ronald A; Abraham, Ann.
Afiliación
  • Jester ELE; 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, USA; and.
  • Loader JI; 2 RJ Hill Laboratories Ltd., Private Bag 3205, Hamilton 3240, New Zealand.
  • Quintana HAF; 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, USA; and.
  • Said KRE; 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, USA; and.
  • Benner RA; 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, USA; and.
  • Abraham A; 1 U.S. Food and Drug Administration, Division of Seafood Science and Technology, Gulf Coast Seafood Laboratory, 1 Iberville Drive, Dauphin Island, Alabama 36528, USA; and.
J Food Prot ; 81(4): 677-683, 2018 04.
Article en En | MEDLINE | ID: mdl-29557672
The use of chloramphenicol (CAP) in aquaculture products is banned in many countries, including the United States, due to human health issues. Very few depletion and metabolism studies of CAP in seafood have been performed. Current detection methods for CAP residues in food are directed toward the parent drug molecule, but rapid elimination following treatment suggests the need for an alternative marker residue. We identified, characterized, and determined the persistence of two CAP metabolites, CAP-base (CAP-B) and CAP-alcohol (CAP-OH), in crab and shrimp. Interday recoveries of CAP, CAP-B, and CAP-OH in muscle fortified ( n = 9) at levels of 0.15 to 0.60 ng/g ranged from 95 to 127% and 101 to 119% for crab and shrimp, respectively, with repeatability ranging from 4 to 19%. The limit of detection for CAP and metabolites in crab and shrimp ranged from 0.05 to 0.11 ng/g. We also monitored the depletion of CAP, CAP-B, and CAP-OH in crab following waterborne exposures. To our knowledge, we present the first CAP depletion and metabolite study following waterborne exposure in crabs, with the aim of identifying alternative marker residues.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Residuos de Medicamentos / Contaminación de Alimentos / Cloranfenicol / Braquiuros / Palaemonidae Límite: Animals Idioma: En Revista: J Food Prot Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Residuos de Medicamentos / Contaminación de Alimentos / Cloranfenicol / Braquiuros / Palaemonidae Límite: Animals Idioma: En Revista: J Food Prot Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos