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Insulin-like factor-2 receptor rs9456497 G genotype overrepresents in males of average population and its correlation with cardiovascular risks.
Huang, Ling; Peng, Jun-Hua; Liang, Qing-Hua; Yin, Rui-Xing; Liu, Cheng-Wu; Pan, Shang-Ling; Huang, Hao; Wu, Hua-Yu; Gan, Rui-Jing; Tang, Lan-Ying; Zhu, Li-Na; Xu, Yan-Zhen; Chen, Si-Bang; Zhou, Xiao-Ling.
Afiliación
  • Huang L; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: huangling@stu.gxmu.edu.cn
  • Peng JH; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Key Laboratory of Longevity and Aging-Related
  • Liang QH; Department of Neurology, Jiangbin Hospital of Guangxi Zhuang Autonomous Region, 85 Hedi Road, Nanning 530021, Guangxi, China. Electronic address: ytx7821@126.com.
  • Yin RX; Department of Cardiology, The First Affiliated Hospital of Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: yinruixing@gxmu.edu.cn.
  • Liu CW; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: liucw@gxmu.edu.cn.
  • Pan SL; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Guangxi Colleges and Universities Key Laboratory of Human Development and Disease Research, 22 Shuangyong Road, Nanning 530021, Guangxi, China; Key Laboratory of Longevity and Aging-Related
  • Huang H; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: haohuang@stu.gxmu.edu.cn.
  • Wu HY; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: wuhuayu@gxmu.edu.cn.
  • Gan RJ; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: ganruijing@gxmu.edu.cn.
  • Tang LY; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: tanglanying@stu.gxmu.edu.cn.
  • Zhu LN; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: zhulina@stu.gxmu.edu.cn.
  • Xu YZ; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: xuyanzhen@stu.gxmu.edu.cn.
  • Chen SB; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: chensibang@stu.gxmu.edu.cn.
  • Zhou XL; Department of Pathophysiology, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, Guangxi, China. Electronic address: zhouxiaoling@gxmu.edu.cn.
Arch Gerontol Geriatr ; 76: 202-209, 2018.
Article en En | MEDLINE | ID: mdl-29554514
OBJECTIVES: To look at the possible effect of IGF2R rs9456497 on cardiovascular risks in a long-lived population. METHODS: IGF-2R rs9456497 was genotyped by iMLDR for 496 long-lived Zhuang Chinese (90-107 y/o) and their offspring (n = 723, 60-75 y/o) and healthy controls (n = 611, 60-75 y/o). Association analyses were then conducted among genotypes and cardiovascular risks. RESULTS: The G genotype (GA/GG) was found to represent more frequently in males of general population. No significantly difference was detected among genotypes in each group except that G genotype tended to reduce the systolic blood pressure (SBP) and diastolic blood pressure (DBP) levels in longevity group. However, after sex stratification, total cholesterol (TC) of each genotype in offspring males was elevated versus relevant genotype in longevity and control group; the triglyceride (TG), fasting plasma glucose (FPG) and BMI of each genotype in longevity group were lower while SBP and DBP were higher than that of the relevant genotype in offspring and controls. After stratified by lipid status, the frequency of G allele was markedly increased in the dyslipidemic subgroup in the combined population and controls. Linear regressive analyses showed that HDL was positively correlated to rs9456497 GA genotype while BMI was negatively correlated to AA genotype in offspring group, whereas TC and TG were reversely while BMI was positively associated with AA genotype in CG. CONCLUSIONS: IGF-2R rs9456497 G genotype correlates to detrimental cardiovascular risks in ordinary population which might partially interpret their less preservation of health as compared to long-lived cohort.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Receptor IGF Tipo 2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades Cardiovasculares / Receptor IGF Tipo 2 Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Revista: Arch Gerontol Geriatr Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos