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Modality switching between therapy and imaging based on the excitation wavelength dependence of dual-function agents in folic acid-conjugated graphene oxides.
Jun, Seung Won; Kwon, Junyoung; Chun, Soo Kyung; Lee, Hyun Ah; Lee, Jaebeom; Hwang, Dae Youn; Dong, Chen-Yuan; Kim, Chang-Seok.
Afiliación
  • Jun SW; Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, South Korea.
  • Kwon J; The first two authors contributed equally to this work.
  • Chun SK; Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, South Korea.
  • Lee HA; The first two authors contributed equally to this work.
  • Lee J; Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, South Korea.
  • Hwang DY; Department of Biomaterials Science, Pusan National University, Miryang 50463, South Korea.
  • Dong CY; Department of Cogno-Mechatronics Engineering, Pusan National University, Busan 46241, South Korea.
  • Kim CS; Department of Biomaterials Science, Pusan National University, Miryang 50463, South Korea.
Biomed Opt Express ; 9(2): 705-716, 2018 Feb 01.
Article en En | MEDLINE | ID: mdl-29552406
Owing to its near infrared (NIR) absorption, graphene oxide (GO) is promising for both photothermal (PT) therapy and multiphoton (MP) imaging. Novel therapy/imaging modality switching is proposed here based on the selected excitation wavelength of femtosecond (FS) laser. GO-based destruction of cancer cells is demonstrated when the laser power of 800-nm-wavelength FS laser is increased above 7 mW. However, GO-based imaging is mainly monitored without damaging the sample when using 1200-nm wavelength FS laser in the same laser power range. Folic acid (FA) conjugated graphene oxide (FA-GO) was synthesized for selective cancer cell targeting. Dual-function FA-GO-based cancer cell targeting agents were experimentally optimized to enable therapy/imaging modality switching.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Biomed Opt Express Año: 2018 Tipo del documento: Article País de afiliación: Corea del Sur Pais de publicación: Estados Unidos