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Design, synthesis, biological evaluation and in vivo testing of dual phosphodiesterase 5 (PDE5) and histone deacetylase 6 (HDAC6)-selective inhibitors for the treatment of Alzheimer's disease.
Rabal, Obdulia; Sánchez-Arias, Juan A; Cuadrado-Tejedor, Mar; de Miguel, Irene; Pérez-González, Marta; García-Barroso, Carolina; Ugarte, Ana; Estella-Hermoso de Mendoza, Ander; Sáez, Elena; Espelosin, Maria; Ursua, Susana; Haizhong, Tan; Wei, Wu; Musheng, Xu; Garcia-Osta, Ana; Oyarzabal, Julen.
Afiliación
  • Rabal O; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Sánchez-Arias JA; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Cuadrado-Tejedor M; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain; Anatomy Department, School of Medicine, University of Navarra, Irunlarrea 1, E-31008, Pamplona, Spain.
  • de Miguel I; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Pérez-González M; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • García-Barroso C; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Ugarte A; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Estella-Hermoso de Mendoza A; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Sáez E; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Espelosin M; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Ursua S; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Haizhong T; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, 4th Avenue, Tianjin, 300456, PR China.
  • Wei W; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, 4th Avenue, Tianjin, 300456, PR China.
  • Musheng X; WuXi Apptec (Tianjin) Co. Ltd., TEDA, No. 111 HuangHai Road, 4th Avenue, Tianjin, 300456, PR China.
  • Garcia-Osta A; Neurobiology of Alzheimer's Disease, Neurosciences Division, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain.
  • Oyarzabal J; Small Molecule Discovery Platform, Molecular Therapeutics Program, Center for Applied Medical Research (CIMA), University of Navarra, Avenida Pio XII 55, E-31008, Pamplona, Spain. Electronic address: julenoyarzabal@unav.es.
Eur J Med Chem ; 150: 506-524, 2018 Apr 25.
Article en En | MEDLINE | ID: mdl-29549837
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Enfermedad de Alzheimer / Histona Desacetilasa 6 Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Francia
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Fosfodiesterasas de Nucleótidos Cíclicos Tipo 5 / Inhibidores de Histona Desacetilasas / Inhibidores de Fosfodiesterasa 5 / Enfermedad de Alzheimer / Histona Desacetilasa 6 Límite: Humans Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article País de afiliación: España Pais de publicación: Francia