Your browser doesn't support javascript.
loading
HRG C633T polymorphism and risk of gestational hypertensive disorders: a pilot study.
Elenis, Evangelia; Skalkidou, Alkistis; Skoog-Svanberg, Agneta; Sydsjö, Gunilla; Stavreus-Evers, Anneli; Åkerud, Helena.
Afiliación
  • Elenis E; Department of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden. evangelia.elenis@kbh.uu.se.
  • Skalkidou A; Department of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
  • Skoog-Svanberg A; Department of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
  • Sydsjö G; Obstetrics and gynaecology, Department of Clinical and Experimental Medicine, Faculty of Health Sciences, Linköping University, Linköping, Sweden.
  • Stavreus-Evers A; Department of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
  • Åkerud H; Department of Women's and Children's Health, Uppsala University, -751 85, Uppsala, SE, Sweden.
BMC Med Genet ; 19(1): 44, 2018 03 14.
Article en En | MEDLINE | ID: mdl-29540166
BACKGROUND: Preeclampsia and gestational hypertensive disorders are thought to occur due to endothelial cell dysfunction and abnormal placentation, triggered by angiogenesis-related factors yet undetermined. The aim of this study was to investigate whether a genetic polymorphism (SNP) of Histidine-rich glycoprotein (HRG), HRG C633T SNP, is associated with gestational hypertensive disorders. METHODS: It was performed a nested case-control study from the BASIC Cohort of Uppsala University Hospital comprising 92 women diagnosed with gestational hypertensive disorders without other comorbidities and 200 women with full term uncomplicated pregnancies, all genotyped regarding HRG C633T SNP. RESULTS: The genetic analysis of the study sample showed that C/C genotype was more prevalent among controls. The presence of the T-allele showed a tendency towards an increased risk of gestational hypertensive disorders. After clustering the study participants based on their genotype, it was observed that the odds for gestational hypertensive disorders among heterozygous C/T or homozygous T/T carriers were higher compared to homozygous C/C carriers [OR 1.72, 95% CI (1.04-2.84)]. The association remained significant even after adjustment for maternal age, BMI and parity. CONCLUSIONS: The HRG C633T genotype seems to be associated with gestational hypertensive disorders, and as part of a greater algorithm, might contribute in the future to the prediction of the individual susceptibility to the condition.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Polimorfismo de Nucleótido Simple / Hipertensión Inducida en el Embarazo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Med Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Proteínas / Polimorfismo de Nucleótido Simple / Hipertensión Inducida en el Embarazo Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: BMC Med Genet Asunto de la revista: GENETICA MEDICA Año: 2018 Tipo del documento: Article País de afiliación: Suecia Pais de publicación: Reino Unido