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Nephronectin is Correlated with Poor Prognosis in Breast Cancer and Promotes Metastasis via its Integrin-Binding Motifs.
Steigedal, Tonje S; Toraskar, Jimita; Redvers, Richard P; Valla, Marit; Magnussen, Synnøve N; Bofin, Anna M; Opdahl, Signe; Lundgren, Steinar; Eckhardt, Bedrich L; Lamar, John M; Doherty, Judy; Hynes, Richard O; Anderson, Robin L; Svineng, Gunbjørg.
Afiliación
  • Steigedal TS; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; David H Koch Institute for Integrative Cancer Research, Massachusetts
  • Toraskar J; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Central Norway Regional Health Authority, Stjørdal, Norway.
  • Redvers RP; Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia.
  • Valla M; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway.
  • Magnussen SN; Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.
  • Bofin AM; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway.
  • Opdahl S; Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, NTNU, Trondheim, Norway.
  • Lundgren S; Department of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology (NTNU), Trondheim, Norway; Cancer Clinic, St. Olav's Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Eckhardt BL; Morgan Welch Inflammatory Breast Cancer Research Program and Clinic, The University of Texas at MD Anderson Cancer Centre, Houston, TX, USA; Section of Translational Breast Cancer Research, The University of Texas at MD Anderson Cancer Centre, Houston, TX, USA; Department of Breast Medical Oncology,
  • Lamar JM; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States; Department of Molecular and Cellular Physiology, Albany Medical College, Albany, NY, USA.
  • Doherty J; Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia.
  • Hynes RO; David H Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, United States; Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA, United States.
  • Anderson RL; Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia; Olivia Newton-John Cancer Research Institute, Heidelberg, Victoria, Australia; School of Cancer Medicine, La Trobe University, Bundoora, Victoria, Australia.
  • Svineng G; Department of Medical Biology, Faculty of Health Sciences, UiT - The Arctic University of Norway, Tromsø, Norway.
Neoplasia ; 20(4): 387-400, 2018 04.
Article en En | MEDLINE | ID: mdl-29539586
Most cancer patients with solid tumors who succumb to their illness die of metastatic disease. While early detection and improved treatment have led to reduced mortality, even for those with metastatic cancer, some patients still respond poorly to treatment. Understanding the mechanisms of metastasis is important to improve prognostication, to stratify patients for treatment, and to identify new targets for therapy. We have shown previously that expression of nephronectin (NPNT) is correlated with metastatic propensity in breast cancer cell lines. In the present study, we provide a comprehensive analysis of the expression pattern and distribution of NPNT in breast cancer tissue from 842 patients by immunohistochemical staining of tissue microarrays from a historic cohort. Several patterns of NPNT staining were observed. An association between granular cytoplasmic staining (in <10% of tumor cells) and poor prognosis was found. We suggest that granular cytoplasmic staining may represent NPNT-positive exosomes. We found that NPNT promotes adhesion and anchorage-independent growth via its integrin-binding and enhancer motifs and that enforced expression in breast tumor cells promotes their colonization of the lungs. We propose that NPNT may be a novel prognostic marker in a subgroup of breast cancer patients.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Integrinas / Proteínas de la Matriz Extracelular / Metástasis de la Neoplasia Tipo de estudio: Prognostic_studies / Screening_studies Límite: Aged / Animals / Female / Humans Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Integrinas / Proteínas de la Matriz Extracelular / Metástasis de la Neoplasia Tipo de estudio: Prognostic_studies / Screening_studies Límite: Aged / Animals / Female / Humans Idioma: En Revista: Neoplasia Asunto de la revista: NEOPLASIAS Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos