The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPAR&#945; pathway.

Zhang, Deqiang; Tong, Xin; Nelson, Bradley B; Jin, Ethan; Sit, Julian; Charney, Nicholas; Yang, Meichan; Omary, M Bishr; Yin, Lei

The hepatic BMAL1/AKT/lipogenesis axis protects against alcoholic liver disease in mice via promoting PPARα pathway.

Zhang, Deqiang; Tong, Xin; Nelson, Bradley B; Jin, Ethan; Sit, Julian; Charney, Nicholas; Yang, Meichan; Omary, M Bishr; Yin, Lei.

Afiliación

Zhang D; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Tong X; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Nelson BB; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Jin E; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Sit J; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Charney N; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Yang M; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Omary MB; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.
Yin L; Department of Molecular & Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI.

Hepatology ; 68(3): 883-896, 2018 09.

Article en En | MEDLINE | ID: mdl-29534306

Asunto(s)

Factores de Transcripción ARNTL/metabolismo; Hepatocitos/metabolismo; Lipogénesis; Hepatopatías Alcohólicas/metabolismo; PPAR alfa/metabolismo; Animales; Factores de Transcripción Básicos con Cremalleras de Leucinas y Motivos Hélice-Asa-Hélice/metabolismo; Femenino; Hepatopatías Alcohólicas/etiología; Macrófagos/metabolismo; Masculino; Ratones Endogámicos C57BL; Ratones Noqueados; Proteínas Proto-Oncogénicas c-akt/metabolismo

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hepatocitos / PPAR alfa / Lipogénesis / Factores de Transcripción ARNTL / Hepatopatías Alcohólicas Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Animals Idioma: En Revista: Hepatology Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos

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