Structural Insights into the Inhibition of Zika Virus NS2B-NS3 Protease by a Small-Molecule Inhibitor.

Li, Yan; Zhang, Zhenzhen; Phoo, Wint Wint; Loh, Ying Ru; Li, Rong; Yang, Hai Yan; Jansson, Anna E; Hill, Jeffrey; Keller, Thomas H; Nacro, Kassoum; Luo, Dahai; Kang, CongBao

Li, Yan; Zhang, Zhenzhen; Phoo, Wint Wint; Loh, Ying Ru; Li, Rong; Yang, Hai Yan; Jansson, Anna E; Hill, Jeffrey; Keller, Thomas H; Nacro, Kassoum; Luo, Dahai; Kang, CongBao.

Afiliación

Li Y; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Zhang Z; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore.
Phoo WW; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore; School of Biological Sciences, Nanyang Techn
Loh YR; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Li R; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Yang HY; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Jansson AE; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Hill J; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Keller TH; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore.
Nacro K; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic addre
Luo D; Lee Kong Chian School of Medicine, Nanyang Technological University, EMB 03-07, 59 Nanyang Drive, Singapore 636921, Singapore; NTU Institute of Structural Biology, Nanyang Technological University, EMB 06-01, 59 Nanyang Drive, Singapore 636921, Singapore. Electronic address: luodahai@ntu.edu.sg.
Kang C; Experimental Therapeutics Centre, Agency for Science, Technology and Research (A(∗)STAR), 31 Biopolis way, Nanos, #03-01, Singapore 138669, Singapore. Electronic address: cbkang@etc.a-star.edu.sg.

Structure ; 26(4): 555-564.e3, 2018 04 03.

Article en En | MEDLINE | ID: mdl-29526431

Asunto(s)

Antivirales/química; Inhibidores de Proteasas/química; Bibliotecas de Moléculas Pequeñas/química; Proteínas no Estructurales Virales/química; Virus Zika/química; Secuencia de Aminoácidos; Antivirales/metabolismo; Sitios de Unión; Clonación Molecular; Cristalografía por Rayos X; Escherichia coli/genética; Escherichia coli/metabolismo; Expresión Génica; Vectores Genéticos/química; Vectores Genéticos/metabolismo; Cinética; Modelos Moleculares; Inhibidores de Proteasas/metabolismo; Unión Proteica; Conformación Proteica en Hélice alfa; Conformación Proteica en Lámina beta; Dominios y Motivos de Interacción de Proteínas; ARN Helicasas/antagonistas & inhibidores; ARN Helicasas/química; ARN Helicasas/genética; ARN Helicasas/metabolismo; Proteínas Recombinantes/química; Proteínas Recombinantes/genética; Proteínas Recombinantes/metabolismo; Serina/química; Serina/metabolismo; Serina Endopeptidasas/química; Serina Endopeptidasas/genética; Serina Endopeptidasas/metabolismo; Bibliotecas de Moléculas Pequeñas/metabolismo; Especificidad por Sustrato; Proteínas no Estructurales Virales/antagonistas & inhibidores; Proteínas no Estructurales Virales/genética; Proteínas no Estructurales Virales/metabolismo; Virus Zika/enzimología; Virus Zika/genética

Palabras clave

Zika virus; drug discovery; protease; protease inhibitor; protein dynamics; structure

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Inhibidores de Proteasas / Proteínas no Estructurales Virales / Bibliotecas de Moléculas Pequeñas / Virus Zika Idioma: En Revista: Structure Asunto de la revista: BIOLOGIA MOLECULAR / BIOQUIMICA / BIOTECNOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Singapur Pais de publicación: Estados Unidos

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google