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A 6-week laboratory research rotation in pharmacogenomics: a model for preparing pharmacy students to practice precision medicine.
Rao, Prema S; Endicott, Ryan; Mullins, Randy; Rao, U Subrahmanyeswara.
Afiliación
  • Rao PS; Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA, 24631, USA.
  • Endicott R; Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA, 24631, USA.
  • Mullins R; Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA, 24631, USA.
  • Rao US; Department of Pharmaceutical Sciences, Appalachian College of Pharmacy, Oakwood, VA, 24631, USA. usrao@acp.edu.
Pharmacogenomics J ; 18(4): 601-608, 2018 07.
Article en En | MEDLINE | ID: mdl-29520079
Comparison of human genome sequences from different individuals has unraveled that genes involved in the drug efficacy and metabolism are polymorphic, harboring mutations, splicing variations and other alterations. These data provide a reasonable explanation for the inter-individual variations observed in drug therapy. Thus, a detailed molecular analysis and an in-depth knowledge of these genes is a prerequisite to practice pharmacogenomics-based medicine. We have introduced a 6-week laboratory research rotation to train students in the expression analysis of different pharmacogenes combined with bioinformatics tools. Students were first introduced to the bioinformatics tools to identify appropriate DNA primers to amplify specific pharmacogenes from the laboratory cancer cell lines. The amplified DNA fragments were sequenced. Finally, students were trained in bioinformatics tools to establish the identity of these DNA sequences. The possible implications of this laboratory training in developing problem-solving skills needed in the implementation of pharmacogenomics knowledge in the clinic, are discussed.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Estudiantes de Farmacia / Educación en Farmacia / Medicina de Precisión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Farmacogenética / Estudiantes de Farmacia / Educación en Farmacia / Medicina de Precisión Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: Pharmacogenomics J Asunto de la revista: BIOLOGIA MOLECULAR / FARMACOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos