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Sulfur-Containing Monoterpenoids as Potential Antithrombotic Drugs: Research in the Molecular Mechanism of Coagulation Activity Using Pinanyl Sulfoxide as an Example.
Nikitina, Liliya E; Kiselev, Sergei V; Startseva, Valeriya A; Bodrov, Andrei V; Azizova, Zulfiya R; Shipina, Olga T; Fedyunina, Inna V; Boichuk, Sergei V; Lodochnikova, Olga A; Klochkov, Vladimir V; Galiullina, Leisan F; Khaliullina, Aliya V.
Afiliación
  • Nikitina LE; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Kiselev SV; Medical Physics Department, Institute of Physics, Kazan Federal University, Kazan, Russia.
  • Startseva VA; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Bodrov AV; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Azizova ZR; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Shipina OT; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Fedyunina IV; Department of Chemistry and Technology of Macromolecular Compounds, Kazan National Research Technological University, Kazan, Russia.
  • Boichuk SV; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Lodochnikova OA; Department of General and Organic Chemistry, Kazan State Medical University, Kazan, Russia.
  • Klochkov VV; A.E. Arbuzov Institute of Organic and Physical Chemistry, Kazan Scientific Center, Russian Academy of Sciences, Kazan, Russia.
  • Galiullina LF; Medical Physics Department, Institute of Physics, Kazan Federal University, Kazan, Russia.
  • Khaliullina AV; Medical Physics Department, Institute of Physics, Kazan Federal University, Kazan, Russia.
Front Pharmacol ; 9: 116, 2018.
Article en En | MEDLINE | ID: mdl-29515444
In this article we present the synthesis of enantiomerically pure sulfoxide and study the influence of this compound on hemostasis. Detailed NMR studies and molecular dynamics simulations using sodium dodecyl sulfate (SDS) membrane models indicated that the bicyclic fragment of sulfoxide was embedded into the SDS micelle whereas the -SO(CH2)2OH fragment remained on the surface of the micelle and was in contact with the solvent. We also found that the pro-coagulative activity of sulfoxide was due to its ability to inhibit platelet activation and inhibited the catalytic activity of phospholipid surface which was involved in formation of coagulation clotting factor complexes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza
Texto completo
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Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Front Pharmacol Año: 2018 Tipo del documento: Article País de afiliación: Rusia Pais de publicación: Suiza