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ULBP1 is induced by hepatitis C virus infection and is the target of the NK cell-mediated innate immune response in human hepatocytes.
Dansako, Hiromichi; Imai, Hirotaka; Ueda, Youki; Satoh, Shinya; Wakita, Takaji; Kato, Nobuyuki.
Afiliación
  • Dansako H; Department of Tumor Virology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
  • Imai H; Department of Tumor Virology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
  • Ueda Y; Department of Tumor Virology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
  • Satoh S; Department of Tumor Virology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
  • Wakita T; Department of Virology II National Institute of Infectious Disease Tokyo Japan.
  • Kato N; Department of Tumor Virology Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama Japan.
FEBS Open Bio ; 8(3): 361-371, 2018 03.
Article en En | MEDLINE | ID: mdl-29511613
Natural killer (NK) cells through their NK group 2 member D (NKG2D) receptors recognize NKG2D ligands such as UL16-binding proteins (ULBPs) on virus-infected cells and subsequently trigger the host innate immune response. In the present study, we demonstrated that hepatitis C virus (HCV) induced the cell surface expression of ULBP1 in human immortalized hepatocyte PH5CH8 cells and human hepatoma HuH-7 cell-derived RSc cells. Interestingly, NK cell line NK-92 induced cytotoxicity and interferon-γ mRNA expression and subsequently reduced the levels of HCV RNA replication during co-culture with HCV-infected RSc cells. From these results, we conclude that ULBP1 is a target of the NK cell-mediated innate immune response in HCV-infected human hepatocytes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: FEBS Open Bio Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: FEBS Open Bio Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido