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Chlamydiae in febrile children with respiratory tract symptoms and age-matched controls, Ghana.
Bühl, H; Eibach, D; Nagel, M; Greub, G; Borel, N; Sarpong, N; Rettig, T; Pesch, T; Aeby, S; Klöckner, A; Brunke, M; Krannich, S; Kreuels, B; Owusu-Dabo, E; Hogan, B; May, J; Henrichfreise, B.
Afiliación
  • Bühl H; Institute for Pharmaceutical Microbiology, University Clinic, University of Bonn, Germany.
  • Eibach D; Bernhard Nocht Institute for Tropical Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany.
  • Nagel M; German Center for Infection Research (DZIF), Hamburg-Borstel-Lübeck, Germany.
  • Greub G; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
  • Borel N; Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland.
  • Sarpong N; Institute of Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Zurich, Switzerland.
  • Rettig T; German Center for Infection Research (DZIF), Hamburg-Borstel-Lübeck, Germany.
  • Pesch T; Agogo Presbyterian Hospital, Department of Child Health, Agogo, Ghana.
  • Aeby S; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
  • Klöckner A; Institute of Veterinary Pathology, University of Zurich, Vetsuisse Faculty, Zurich, Switzerland.
  • Brunke M; Institute of Microbiology, University Hospital Center and University of Lausanne, Switzerland.
  • Krannich S; Institute for Pharmaceutical Microbiology, University Clinic, University of Bonn, Germany.
  • Kreuels B; German Center for Infection Research (DZIF), Bonn, Germany.
  • Owusu-Dabo E; Institute for Pharmaceutical Microbiology, University Clinic, University of Bonn, Germany.
  • Hogan B; Institute for Pharmaceutical Microbiology, University Clinic, University of Bonn, Germany.
  • May J; Division of Tropical Medicine, I. Department of Internal Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany.
  • Henrichfreise B; Kumasi Centre for Collaborative Research in Tropical Medicine (KCCR), Kumasi, Ghana.
New Microbes New Infect ; 22: 44-48, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29511568
Members of the Chlamydiales order are obligate intracellular pathogens causing acute and chronic infectious diseases. Chlamydiaceae are established agents of community- and zoonotically acquired respiratory tract infections, and emerging pathogens among the Chlamydia-related bacteria have been implicated in airway infections. The role of both in airway infections in Africa is underexplored. We performed a case -control study on the prevalence of Chlamydiaceae and Chlamydia-related emerging pathogens in children with febrile respiratory tract infections in West Africa, Ghana. Using a pan-Chlamydiales broad-range real-time PCR, we detected chlamydial DNA in 11 (1.9%) of 572 hospitalized febrile children with respiratory tract symptoms and in 24 (4.3%) of 560 asymptomatic age-matched controls (p 0.03). Chlamydiaceae were found to be common among both symptomatic and healthy Ghanaian children, with Chlamydia pneumoniae being the most prevalent species. Parachlamydiaceae were detected in two children without symptoms but not in the symptomatic group. We identified neither Chlamydia psittaci nor Simkania negevensis but a member of a new chlamydial family that shared 90.2% sequence identity with the 16S rRNA gene of the zoonotic pathogen Chlamydia pecorum. In addition, we found a new Chlamydia-related species that belonged to a novel family sharing 91.3% 16S rRNA sequence identity with Candidatus Syngnamydia venezia. The prevalence and spectrum of chlamydial species differed from previous results obtained from children of other geographic regions and our study indicates that both, Chlamydiaceae and Chlamydia-related bacteria, are not clearly linked to clinical symptoms in Ghanaian children.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: New Microbes New Infect Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies / Observational_studies / Risk_factors_studies Idioma: En Revista: New Microbes New Infect Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido