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Patient-Specific Flow Descriptors and Normalized wall index in Peripheral Artery Disease: a Preliminary Study.
Singh, Jaykrishna; Brunner, Gerd; Morrisett, Joel D; Ballantyne, Christie M; Lumsden, Alan B; Shah, Dipan J; Decuzzi, Paolo.
Afiliación
  • Singh J; Department of Translational Imaging, The Houston Methodist Research Institute (HMRI), Houston, TX.
  • Brunner G; Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX.
  • Morrisett JD; Methodist DeBakey Heart & Vascular Center, The Houston Methodist Research Institute (HMRI), Houston, TX.
  • Ballantyne CM; Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX.
  • Lumsden AB; Methodist DeBakey Heart & Vascular Center, The Houston Methodist Research Institute (HMRI), Houston, TX.
  • Shah DJ; Division of Atherosclerosis and Vascular Medicine, Department of Medicine, Baylor College of Medicine, Houston, TX.
  • Decuzzi P; Methodist DeBakey Heart & Vascular Center, The Houston Methodist Research Institute (HMRI), Houston, TX.
Comput Methods Biomech Biomed Eng Imaging Vis ; 6(2): 119-127, 2018.
Article en En | MEDLINE | ID: mdl-29503774
BACKGROUND AND AIMS: MRI-based hemodynamics have been applied to study the relationship between time-averaged wall shear stresses (TAWSS), oscillatory shear index (OSI) and atherosclerotic lesions in the coronary arteries, carotid artery, and human aorta. However, the role of TAWSS and OSI are poorly understood in lower extremity arteries. The aim of this work was to investigate the feasibility of hemodynamic assessment of the superficial femoral artery (SFA) in patients with peripheral artery disease (PAD) and we hypothesized that there is an association between TAWSS and OSI, respectively, and atherosclerotic burden expressed as the normalized wall index (NWI). METHODS: Six cases of 3D vascular geometries of the SFA and related inlet/outlet flow conditions were extracted from patient-specific MRI data including baseline, 12 and 24 months. Blood flow simulations were performed to compute flow descriptors, including TAWSS and OSI, and NWI. RESULTS: NWI was correlated positively with TAWSS (correlation coefficient: r = 0.592; p < 0.05). NWI was correlated negatively with OSI (correlation coefficient: r = -0.310, p < 0.01). Spatially averaged TAWSS and average NWI increased significantly between baseline and 24-months, whereas OSI decreased over 2-years. CONCLUSIONS: In this pilot study with a limited sample size, TAWSS was positively associated with NWI, a measure of plaque burden, whereas OSI showed an inverse relationship. However, our findings need to be verified in a larger prospective study. MRI-based study of hemodynamics is feasible in the superficial femoral artery.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Comput Methods Biomech Biomed Eng Imaging Vis Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Imprimir
XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Observational_studies / Risk_factors_studies Idioma: En Revista: Comput Methods Biomech Biomed Eng Imaging Vis Año: 2018 Tipo del documento: Article Pais de publicación: Reino Unido