Design, synthesis, and biological evaluation of stable ß<sup>6.3</sup>-Helices: Discovery of non-hemolytic antibacterial peptides.

Reddy, Damodara N; Singh, Sukrit; Ho, Chris M W; Patel, Janki; Schlesinger, Paul; Rodgers, Stephen; Doctor, Allan; Marshall, Garland R

Design, synthesis, and biological evaluation of stable ß^6.3-Helices: Discovery of non-hemolytic antibacterial peptides.

Reddy, Damodara N; Singh, Sukrit; Ho, Chris M W; Patel, Janki; Schlesinger, Paul; Rodgers, Stephen; Doctor, Allan; Marshall, Garland R.

Afiliación

Reddy DN; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: damodarareddyiisc@gmail.com.
Singh S; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ho CMW; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Patel J; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Schlesinger P; Department of Cell Biology & Physiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Rodgers S; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Doctor A; Department of Pediatrics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Marshall GR; Department of Biochemistry & Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: garlandm@gmail.com.

Eur J Med Chem ; 149: 193-210, 2018 Apr 10.

Article en En | MEDLINE | ID: mdl-29501941

Asunto(s)

Antibacterianos/síntesis química; Diseño de Fármacos; Hemólisis/efectos de los fármacos; Peptidomiméticos/síntesis química; Antibacterianos/farmacología; Dipéptidos/química; Modelos Moleculares; Simulación de Dinámica Molecular; Peptidomiméticos/química; Peptidomiméticos/farmacología; Prolina/análogos & derivados; Prolina/química; Estructura Secundaria de Proteína

Palabras clave

Antibiotic; Azaproline foldamers; Gramicidin; Liposomes and beta-helices; RBC hemolysis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diseño de Fármacos / Peptidomiméticos / Hemólisis / Antibacterianos Tipo de estudio: Prognostic_studies Idioma: En Revista: Eur J Med Chem Año: 2018 Tipo del documento: Article Pais de publicación: Francia

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