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Comparative genomics of Mycobacterium reveals evolutionary trends of M. avium complex.
Saha, Mousumi Sarkar; Pal, Shilpee; Sarkar, Indrani; Roy, Ayan; Das Mohapatra, Pradeep K; Sen, Arnab.
Afiliación
  • Saha MS; Bioinformatics Facility, Department of Botany, University of North Bengal, Darjeeling 734013, India.
  • Pal S; Department of Microbiology, Vidyasagar University, Midnapore 721102, India.
  • Sarkar I; Bioinformatics Facility, Department of Botany, University of North Bengal, Darjeeling 734013, India.
  • Roy A; Bioinformatics Facility, Department of Botany, University of North Bengal, Darjeeling 734013, India.
  • Das Mohapatra PK; Department of Microbiology, Raiganj University, Raiganj 733134, India.
  • Sen A; Bioinformatics Facility, Department of Botany, University of North Bengal, Darjeeling 734013, India. Electronic address: senarnab_nbu@hotmail.com.
Genomics ; 111(3): 426-435, 2019 05.
Article en En | MEDLINE | ID: mdl-29501678
Mycobacterium is gram positive, slow growing, disease causing Actinobacteria. Beside potential pathogenic species, Mycobacterium also contains opportunistic pathogens as well as free living non-pathogenic species. Disease related various analyses on Mycobacterium tuberculosis are very widespread. However, genomic study of overall Mycobacterium species for understanding the selection pressure on genes as well as evolution of the organism is still illusive. MLSA and 16s rDNA based analysis has been generated for 241 Mycobacterium strains and a detailed analysis of codon and amino acid usage bias of mycobacterial genes, their functional analysis have been done. Further the evolutionary features of M. avium complex also have been revealed. Mycobacterial genes are moderately GC rich showed higher expression level in PPs and significant negative correlation with biosynthetic cost of proteins. Translational selection pressure was observed in mycobacterial genes. MAC showed close relationship with NPs and higher evolutionary rate in MAC revealed their constant evolving nature.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma Bacteriano / Mycobacterium Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Filogenia / Genoma Bacteriano / Mycobacterium Idioma: En Revista: Genomics Asunto de la revista: GENETICA Año: 2019 Tipo del documento: Article País de afiliación: India Pais de publicación: Estados Unidos