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Melanoma risk prediction using a multilocus genetic risk score in the Women's Health Initiative cohort.
Cho, Hyunje G; Ransohoff, Katherine J; Yang, Lingyao; Hedlin, Haley; Assimes, Themistocles; Han, Jiali; Stefanick, Marcia; Tang, Jean Y; Sarin, Kavita Y.
Afiliación
  • Cho HG; Department of Dermatology, Stanford University School of Medicine, Stanford, California.
  • Ransohoff KJ; Department of Dermatology, Stanford University School of Medicine, Stanford, California.
  • Yang L; Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California.
  • Hedlin H; Quantitative Sciences Unit, Stanford University School of Medicine, Stanford, California.
  • Assimes T; Department of Medicine (Cardiovascular), Stanford University School of Medicine, Stanford, California.
  • Han J; Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, Indiana University, Indianapolis, Indiana.
  • Stefanick M; Stanford Prevention Research Center, Department of Medicine, Stanford University School of Medicine, Stanford, California.
  • Tang JY; Department of Dermatology, Stanford University School of Medicine, Stanford, California.
  • Sarin KY; Department of Dermatology, Stanford University School of Medicine, Stanford, California. Electronic address: ksarin@stanford.edu.
J Am Acad Dermatol ; 79(1): 36-41.e10, 2018 Jul.
Article en En | MEDLINE | ID: mdl-29499294
BACKGROUND: Single-nucleotide polymorphisms (SNPs) associated with melanoma have been identified though genome-wide association studies. However, the combined impact of these SNPs on melanoma development remains unclear, particularly in postmenopausal women who carry a lower melanoma risk. OBJECTIVE: We examine the contribution of a combined polygenic risk score on melanoma development in postmenopausal women. METHODS: Genetic risk scores were calculated using 21 genome-wide association study-significant SNPs. Their combined effect on melanoma development was evaluated in 19,102 postmenopausal white women in the clinical trial and observational study arms of the Women's Health Initiative dataset. RESULTS: Compared to the tertile of weighted genetic risk score with the lowest genetic risk, the women in the tertile with the highest genetic risk were 1.9 times more likely to develop melanoma (95% confidence interval 1.50-2.42). The incremental change in c-index from adding genetic risk scores to age were 0.075 (95% confidence interval 0.041-0.109) for incident melanoma. LIMITATIONS: Limitations include a lack of information on nevi count, Fitzpatrick skin type, family history of melanoma, and potential reporting and selection bias in the Women's Health Initiative cohort. CONCLUSION: Higher genetic risk is associated with increased melanoma prevalence and incidence in postmenopausal women, but current genetic information may have a limited role in risk prediction when phenotypic information is available.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Melanoma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Am Acad Dermatol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Cutáneas / Predisposición Genética a la Enfermedad / Estudio de Asociación del Genoma Completo / Melanoma Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Aged / Female / Humans / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Am Acad Dermatol Año: 2018 Tipo del documento: Article Pais de publicación: Estados Unidos