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Patient-reported outcomes and joint status across subgroups of US adults with hemophilia with varying characteristics: Results from the Pain, Functional Impairment, and Quality of Life (P-FiQ) study.
Batt, Katharine; Boggio, Lisa; Neff, Anne; Buckner, Tyler W; Wang, Michael; Quon, Doris; Witkop, Michelle; Recht, Michael; Kessler, Craig; Iyer, Neeraj N; Cooper, David L.
Afiliación
  • Batt K; Wake Forest School of Medicine, Winston-Salem, NC, USA.
  • Boggio L; Rush University Medical Center, Chicago, IL, USA.
  • Neff A; Cleveland Clinic, Cleveland, OH, USA.
  • Buckner TW; University of Colorado School of Medicine, Aurora, CO, USA.
  • Wang M; University of Colorado School of Medicine, Aurora, CO, USA.
  • Quon D; Orthopaedic Hemophilia Treatment Center, Orthopaedic Institute for Children, Los Angeles, CA, USA.
  • Witkop M; National Hemophilia Foundation, New York, NY, USA.
  • Recht M; Oregon Health & Science University, Portland, OR, USA.
  • Kessler C; Georgetown University Hospital, Washington, DC, USA.
  • Iyer NN; Novo Nordisk Inc., Plainsboro, NJ, USA.
  • Cooper DL; Novo Nordisk Inc., Plainsboro, NJ, USA.
Eur J Haematol ; 100 Suppl 1: 14-24, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29498783
INTRODUCTION: Pain and functional impairment associated with joint disease are major problems for people with hemophilia, and impact on health-related quality of life (HRQoL) may vary across groups defined by demographic and treatment-related characteristics. OBJECTIVE: To evaluate differences in overall HRQoL, pain, function, and joint status between P-FiQ study subgroups. METHODS: Adult males with hemophilia and a history of joint pain/bleeding completed a pain history and the patient-reported outcome instruments EQ-5D-5L, Brief Pain Inventory v2 Short Form (BPI), International Physical Activity Questionnaire (IPAQ), and Hemophilia Activities List (HAL); optionally, joint status was assessed (Hemophilia Joint Health Score v2.1 [HJHS]). Scores were analyzed between subgroups across sets of participant characteristics. RESULTS: A total of 381 adult males with hemophilia were enrolled, with median age of 34 years. Worse scores on EQ-5D-5L index, BPI pain severity/interference, HAL overall score, and HJHS were generally associated with being college educated, unemployment, self-reporting both acute and chronic pain, and self-reporting anxiety/depression. CONCLUSIONS: Measures of joint status and HRQoL were consistently lower in participants who had higher educational levels, were unemployed, self-reported having both acute and chronic pain, and self-reported having anxiety/depression. A greater understanding of the association of these factors with disease outcomes may improve individualized patient management.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemofilia A / Artropatías Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Hemofilia A / Artropatías Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Aspecto: Patient_preference Límite: Adult / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: Eur J Haematol Asunto de la revista: HEMATOLOGIA Año: 2018 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido