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Role of voltage-gated calcium channels on striatal dopamine release induced by inorganic mercury in freely moving rats.
Faro, Lilian R Ferreira; Alfonso, Miguel; Ferreira, Vania Moraes; Durán, Rafael.
Afiliación
  • Faro LRF; Department of Functional Biology and Health Sciences, University of Vigo, Spain. Electronic address: lilianfaro@uvigo.es.
  • Alfonso M; Department of Functional Biology and Health Sciences, University of Vigo, Spain.
  • Ferreira VM; Universidade de Brasilia, Campus Universitario Darcy Ribeiro, Brasília, Brasil.
  • Durán R; Department of Functional Biology and Health Sciences, University of Vigo, Spain.
Environ Toxicol Pharmacol ; 59: 13-16, 2018 Apr.
Article en En | MEDLINE | ID: mdl-29482112
The possible role of voltage-sensitive calcium channels (VSCC) activation on the HgCl2-induced dopamine release was investigated using selective VSCC blockers and the dopamine levels were measured by HPLC from samples obtained by in vivo brain microdialysis. Infusion of HgCl2 in nicardipine (10 or 100 µM) or flunaricine (10 µM) pretreated animals had no significant effect on dopamine release induced by HgCl2. Pretreatment with 100 µM flunaricine, 20 µM ω-conotoxin MVIIC, or ω-conotoxin GVIA significantly decreased the HgCl2-induced dopamine release over 61%, 88%, and 99%, respectively. HgCl2-induced dopamine release could be produced, at least in part, by activation of VSCC at dopaminergic terminals, especially N- and P/Q-type.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Calcio / Dopamina / Cuerpo Estriado / Mercurio Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Imprimir
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PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Canales de Calcio / Dopamina / Cuerpo Estriado / Mercurio Límite: Animals Idioma: En Revista: Environ Toxicol Pharmacol Año: 2018 Tipo del documento: Article Pais de publicación: Países Bajos