Comparison of different treatment modalities of endometriosis in infertile women.
Fertil Steril
; 47(1): 40-4, 1987 Jan.
Article
en En
| MEDLINE
| ID: mdl-2947817
This study was designed to evaluate the effectiveness of three therapeutic modalities in the management of stage I and II endometriosis. Management modalities consisted of no treatment (controls, n = 56); oral medroxyprogesterone acetate (MPA), 30 mg orally per day for 90 days (n = 36); and danazol, 600 to 800 mg daily for 6 months (n = 52). All patients were followed for at least 18 months of exposure to pregnancy. Cumulative pregnancy rates were determined by life-table analysis. At 30 months, pregnancies resulted in 55% of group I (controls), 71% of group II (MPA), and 46% of group III (danazol). There were no significant differences among these rates. Similarly, there was no significant difference between the cumulative pregnancy rates for stage I (59%) and for stage II (57%). Abortion rates for the various treatment modalities were the following: MPA 6.3%, danazol 11%, and no treatment, 14.3%. The spontaneous abortion rate in stage I and stage II disease was not significantly different. The results of this study suggest that a period of expectant management with correction of other infertility factors may be warranted in patients with mild to moderate endometriosis before medical therapy is contemplated.
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Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Neoplasias Pélvicas
/
Pregnadienos
/
Danazol
/
Endometriosis
/
Infertilidad Femenina
/
Medroxiprogesterona
Tipo de estudio:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
Idioma:
En
Revista:
Fertil Steril
Año:
1987
Tipo del documento:
Article
Pais de publicación:
Estados Unidos