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An efficient synthetic protocol for amide derivatives of Boc-2-aminoisobutyrate.
Jo, Minmi; Won, Sun-Woo; Lee, Dong Guk; Jung, Jae-Kyung; Kim, Sunhong; Kwak, Young-Shin.
Afiliación
  • Jo M; College of Pharmacy, Korea University, Sejong, 30019, Korea.
  • Won SW; College of Pharmacy, Korea University, Sejong, 30019, Korea.
  • Lee DG; College of Pharmacy, Korea University, Sejong, 30019, Korea.
  • Jung JK; College of Pharmacy, Chungbuk National University, Chungju, 28160, Korea. orgjkjung@chungbuk.ac.kr.
  • Kim S; Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141, Korea.
  • Kwak YS; College of Pharmacy, Korea University, Sejong, 30019, Korea. youngshin@korea.ac.kr.
Arch Pharm Res ; 41(3): 259-264, 2018 Mar.
Article en En | MEDLINE | ID: mdl-29478110
Aminoisobutyric acid (AIB) is an important building block widely incorporated by medicinal chemists in molecular design. Owing to the steric challenge, elaborating AIB's carboxylic acid using conventional amidation protocols is often problematic. We discovered that an amidation protocol utilizing methyl Boc-aminoisobutyrate and magnesium amidates of various reactivities produces the corresponding amide derivatives in good to excellent yields.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Amidas / Ácidos Aminoisobutíricos Idioma: En Revista: Arch Pharm Res Año: 2018 Tipo del documento: Article Pais de publicación: Corea del Sur
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Química Farmacéutica / Amidas / Ácidos Aminoisobutíricos Idioma: En Revista: Arch Pharm Res Año: 2018 Tipo del documento: Article Pais de publicación: Corea del Sur