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Serum glutathione S-transferase Pi as predictor of the outcome and acute kidney injury in premature newborns.
Stojanovic, Vesna D; Barisic, Nenad A; Radovanovic, Tanja D; Kovac, Natasa B; Djuran, Jelena D; Antic, Amira Peco E; Doronjski, Aleksandra D.
Afiliación
  • Stojanovic VD; School of Medicine, Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, University of Novi Sad, Hajduk Veljkova 10, Novi Sad, 21000, Serbia. vesna.stojanovic@mf.uns.ac.rs.
  • Barisic NA; School of Medicine, Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, University of Novi Sad, Hajduk Veljkova 10, Novi Sad, 21000, Serbia.
  • Radovanovic TD; Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, Novi Sad, Serbia.
  • Kovac NB; Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, Novi Sad, Serbia.
  • Djuran JD; Laboratory for Medical Biochemistry Medlab, Novi Sad, Serbia.
  • Antic APE; University Children Hospital, Belgrade, Serbia.
  • Doronjski AD; School of Medicine, Institute for Child and Youth Health Care of Vojvodina, NICU/PICU, University of Novi Sad, Hajduk Veljkova 10, Novi Sad, 21000, Serbia.
Pediatr Nephrol ; 33(7): 1251-1256, 2018 07.
Article en En | MEDLINE | ID: mdl-29476242
BACKGROUND: The incidence of acute kidney injury (AKI) among the neonates treated at the Neonatal Intensive Care Unit is high with high mortality rates. Glutathione S-transferase (GST) class Pi plays an important role in the protection of cells from cytotoxic and oncogenic agents. The aim of the study was to examine whether the levels of serum glutathione S-transferase Pi (GST Pi) determined after birth have any predictive value for the outcome and development of AKI in premature neonates. METHODS: The prospective study included 36 premature neonates. The data about morbidity was gathered for all the neonates included in the study. The blood samples were taken in the first 6 h of life and GST Pi levels were measured. RESULTS: The mean values and standard deviations of GST Pi among the neonates who died and who survived were 1.904 ± 0.4535 vs 1.434 ± 0.444 ng/ml (p = 0.0128). Logistic regression revealed a statistically significant, positive correlation between GST Pi levels and death (p = 0.0180, OR7.5954; CI 1.4148-40.7748).The mean value of GST Pi levels in the neonates with AKI was higher than in neonates without AKI (p = 0.011). CONCLUSIONS: The conclusion of our study is that high levels of serum GST Pi in the first 6 h after birth are associated with an increased mortality and development of AKI in prematurely born neonates.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Neonatal / Gutatión-S-Transferasa pi / Lesión Renal Aguda / Recien Nacido Extremadamente Prematuro / Pruebas de Función Renal Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Unidades de Cuidado Intensivo Neonatal / Gutatión-S-Transferasa pi / Lesión Renal Aguda / Recien Nacido Extremadamente Prematuro / Pruebas de Función Renal Tipo de estudio: Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Male / Newborn Idioma: En Revista: Pediatr Nephrol Asunto de la revista: NEFROLOGIA / PEDIATRIA Año: 2018 Tipo del documento: Article Pais de publicación: Alemania