Investigation of multi-target-directed ligands (MTDLs) with butyrylcholinesterase (BuChE) and indoleamine 2,3-dioxygenase 1 (IDO1) inhibition: The design, synthesis of miconazole analogues targeting Alzheimer's disease.

Lu, Xin; He, Si-Yu; Li, Qi; Yang, Hongyu; Jiang, Xueyang; Lin, Hongzhi; Chen, Yao; Qu, Wei; Feng, Feng; Bian, Yaoyao; Zhou, You; Sun, Haopeng

Lu, Xin; He, Si-Yu; Li, Qi; Yang, Hongyu; Jiang, Xueyang; Lin, Hongzhi; Chen, Yao; Qu, Wei; Feng, Feng; Bian, Yaoyao; Zhou, You; Sun, Haopeng.

Afiliación

Lu X; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
He SY; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Li Q; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Yang H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Jiang X; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 211198, China.
Lin H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China.
Chen Y; School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Qu W; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 211198, China.
Feng F; Key Laboratory of Biomedical Functional Materials, School of Science, China Pharmaceutical University, Nanjing 211198, China.
Bian Y; School of Nursing, Nanjing University of Chinese Medicine, Nanjing 210023, China.
Zhou Y; College of Biotechnology, Southwest University, Chongqing 400715, China. Electronic address: zhouy701005@swu.edu.cn.
Sun H; Department of Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, China. Electronic address: sunhaopeng@cpu.edu.cn.

Bioorg Med Chem ; 26(8): 1665-1674, 2018 05 01.

Article en En | MEDLINE | ID: mdl-29475581

Asunto(s)

Enfermedad de Alzheimer/tratamiento farmacológico; Butirilcolinesterasa/metabolismo; Diseño de Fármacos; Inhibidores Enzimáticos/farmacología; Indolamina-Pirrol 2,3,-Dioxigenasa/antagonistas & inhibidores; Miconazol/farmacología; Acetilcolinesterasa/metabolismo; Enfermedad de Alzheimer/metabolismo; Enfermedad de Alzheimer/patología; Animales; Relación Dosis-Respuesta a Droga; Electrophorus; Inhibidores Enzimáticos/síntesis química; Inhibidores Enzimáticos/química; Caballos; Humanos; Indolamina-Pirrol 2,3,-Dioxigenasa/metabolismo; Ligandos; Miconazol/síntesis química; Miconazol/química; Simulación del Acoplamiento Molecular; Estructura Molecular; Relación Estructura-Actividad

Palabras clave

Alzheimer's disease; Butyrylcholinesterase (BuChE); Indoleamine 2,3-dioxygenase 1 (IDO1); Miconazole derivatives; Multifunctional agents

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Butirilcolinesterasa / Diseño de Fármacos / Inhibidores Enzimáticos / Indolamina-Pirrol 2,3,-Dioxigenasa / Enfermedad de Alzheimer / Miconazol Límite: Animals / Humans Idioma: En Revista: Bioorg Med Chem Asunto de la revista: BIOQUIMICA / QUIMICA Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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