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Mycobacterium tuberculosis-Infected Hematopoietic Stem and Progenitor Cells Unable to Express Inducible Nitric Oxide Synthase Propagate Tuberculosis in Mice.
Reece, Stephen T; Vogelzang, Alexis; Tornack, Julia; Bauer, Wolfgang; Zedler, Ulrike; Schommer-Leitner, Sandra; Stingl, Georg; Melchers, Fritz; Kaufmann, Stefan H E.
Afiliación
  • Reece ST; Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Vogelzang A; Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Tornack J; Senior Group on Lymphocyte Development, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Bauer W; Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Austria.
  • Zedler U; Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Schommer-Leitner S; Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Stingl G; Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, Medical University of Vienna, Austria.
  • Melchers F; Senior Group on Lymphocyte Development, Max Planck Institute for Infection Biology, Berlin, Germany.
  • Kaufmann SHE; Department of Immunology, Max Planck Institute for Infection Biology, Berlin, Germany.
J Infect Dis ; 217(10): 1667-1671, 2018 04 23.
Article en En | MEDLINE | ID: mdl-29471332
Persistence of Mycobacterium tuberculosis within human bone marrow stem cells has been identified as a potential bacterial niche during latent tuberculosis. Using a murine model of tuberculosis, we show here that bone marrow stem and progenitor cells containing M. tuberculosis propagated tuberculosis when transferred to naive mice, given that both transferred cells and recipient mice were unable to express inducible nitric oxide synthase, which mediates killing of intracellular bacteria via nitric oxide. Our findings suggest that bone marrow stem and progenitor cells containing M. tuberculosis propagate hallmarks of disease if nitric oxide-mediated killing of bacteria is defective.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Tuberculosis / Células Madre Hematopoyéticas / Óxido Nítrico Sintasa de Tipo II / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Infect Dis Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Células Madre / Tuberculosis / Células Madre Hematopoyéticas / Óxido Nítrico Sintasa de Tipo II / Mycobacterium tuberculosis Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Infect Dis Año: 2018 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Estados Unidos